纳他霉素在不同溶剂中溶解度的测定与关联  

Measurement and Correlation of the Solubilities of Natamycin in Different Solvents

作　　者：骆健美[1,2,3] 金志华[1,2] 岑沛霖[2] 王敏 

机构地区：[1]浙江大学宁波理工学院生物与制药工程系,浙江宁波315100 [2]浙江大学材料与化学工程学院化学工程与生物工程学系,浙江杭州310027 [3]天津科技大学生物工程学院天津市工业微生物重点实验室,天津300457

出　　处：《高校化学工程学报》2008年第5期733-738,共6页Journal of Chemical Engineering of Chinese Universities

基　　金：浙江省重大科技攻关项目(2004C13007);天津科技大学引进人才科研启动基金(20060426);天津市应用基础研究计划面上项目(07JCYBJC07800);国际科学基金(F/4239-1)

摘　　要：采用平衡法测定了纳他霉素在纯水(278.15～341.15K)和异丙醇(278.15～318.15K)、甲醇(278.15～313.15K)溶液中的溶解度。在三种溶剂中的溶解度均随温度升高而增大,以在甲醇中溶解效果最好,异丙醇次之,纯水最差。分别用经验模型、理想溶解度方程和Apelblat方程对实验数据进行关联,关联效果令人满意,平均相对误差小于5%,获得了相关模型参数。相对而言,经验模型和Apelblat方程关联的效果较好。实验得到的溶解度数据和关联结果对纳他霉素结晶工艺的研究具有较大的指导意义。The solubilities ofnatamycin in pure water （278.15-341.15 K）, isopropanol （278.15-318.15 K） and methanol （278.15-313.15 K） were determined respectively by the equilibrium method. It was found that all the solubilities in these three solvents increase with the increase of the temperature, and the solving effect of the methanol is the best, the isopropanol is the second and the water is the worst. The solving data of natamycin were well correlated respectively by the empirical model, the solubility equation for ideal solution and the Apelblat equation with relative errors within 5%, and it was found that the empirical model and Apelblat equation are more satisfactory than the solubility equation for ideal solution. The experimental results and correlations obtained would be useful for the technological study of industrial crystallization process of natamycin.

关 键 词：纳他霉素 溶解度 模型关联 平衡法 

分 类 号：O645.12[理学—物理化学] TQ013.1[理学—化学]