Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S)-camptothecins  

作　　者：Di Zao Li Xian Dao Pan Hong Yan Liu Song Wu 

机构地区：[1]Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beifing 100050, China

出　　处：《Chinese Chemical Letters》2008年第10期1202-1205,共4页中国化学快报（英文版）

摘　　要：A series of 5-C-alkylating camptothecins have been synthesized by one-step method, and their in vitro antitumor activity was evaluated against six human cancer cell lines. The results showed that all 5-C-alkylates of camptothecins possessed poor cytotoxicity on six human cancer cell lines.A series of 5-C-alkylating camptothecins have been synthesized by one-step method, and their in vitro antitumor activity was evaluated against six human cancer cell lines. The results showed that all 5-C-alkylates of camptothecins possessed poor cytotoxicity on six human cancer cell lines.

关 键 词：CAMPTOTHECIN SYNTHESIS 5-C-Alkylate Antitumor activity 

分 类 号：R962[医药卫生—药理学]