脑出血急性期外周血sFas和sFas配体水平的观察  

Serum Levels of Soluble Fas and Soluble Fas-ligand in Acute Cerebral Hemorrhage

作　　者：徐沙贝[1] 许峰[1] 杨业新[2] 唐洲平[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,武汉430030 [2]中国地质大学(武汉)医院,武汉430030

出　　处：《华中科技大学学报（医学版）》2008年第5期672-674,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.30770751)

摘　　要：目的观察脑出血急性期外周血可溶性Fas(sFas)和可溶性Fas配体(sFasL)水平,探讨其变化与病情严重程度的关系。方法以急性期脑出血患者为研究组,健康查体者为对照组。利用ELISA方法测定两组外周血sFas和sFasL浓度,比较两组之间sFas和sFasL浓度的差异。结果研究组患者sFas、sFasL血浆浓度分别为(8.45±1.07)ng/L和(2.22±0.41)ng/L,较对照组的(2.72±0.95)ng/L和(0.48±0.17)ng/L明显升高(均P<0.01)。且随着血肿体积增大,sFas、sFasL血浆浓度也相应增高。结论sFas和sFasL可能参与脑出血的病理生理过程,且对于评估病情严重程度有一定意义。Objective To observe the serum levels of soluble Fas and soluble Fas-ligand in acute cerebral hemorrhage patients and discuss the relationship between the changes of their levels and the severity of cerebral hemorrhage. Methods The patients with acute cerebral hemorrhage served as the experimental group and the healthy volunteers as the control group, respectively. The serum levels of soluble Fas and soluble Fas-ligand were measured in both groups by the method of ELISA and the difference in the levels of soluble Fas and soluble Fas-ligand were compared between the two groups. Results The serum levels of soluble Fas and soluble Fas-ligand in the experimental group were （8.45± 1.07） ng/L and （2.22 ±0.41） ng/L respectively, significantly higher than in the control group [（2.72±0. 95） ng/L and （0. 48±0. 17） ng, respectively, P〈0.01]. With the increase in the volume of intracranial hematoma, the levels of soluble Fas and soluble Fas-ligand were also elevated correspondingly. Conclusion The soluble Fas and soluble Fas-ligand probably take roles in the pathophysiological process of cerebral hemorrhage and are valuable to evaluate the severity of disease.

关 键 词：脑出血 可溶性FAS 可溶性FAS配体 

分 类 号：R743.34[医药卫生—神经病学与精神病学]