Elevated expressions of Survivin and VEGF proteins are strong independent predictors of survival in squamous carcinoma of larynx  

凋亡抑制蛋白Survivin和血管内皮生长因子高表达是喉鳞状细胞癌生存预后的独立预测因子(英文)

作　　者：Rong Luo Weijia Kong Yanjun Wang 

机构地区：[1]Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2008年第11期661-665,共5页中德临床肿瘤学杂志（英文版）

基　　金：the grants from the National Outstanding Young Scien- tist Foundation of China (No. 39925035); the National Natural Science Foundations of China (No. 3967078 and No. 30070809)

摘　　要：Objective： To study the relationship between Survivin and VEGF proteins in a subgroup of patients with squarnous carcinoma of larynx. Methods： 108 cases of squamous carcinoma of larynx with clinical data were collected and expressions of Survivin and VEGF in peripheral blood were investigated by enzyme-linked immunosorbent assay （ELISA）. Results： Expressions of Survivin and VEGF were significantly associated with T stage, N stage and metastasis of squamous carcinoma of larynx. The patients with Survivin or VEGF over-expressions presented lower survival rate, respectively, as compared to those of low-expression （P 〈 0.05）. The survival rate in squamous carcinoma of larynx patients with Survivin and VEGF dual over-expressions was significantly lower than that of patients with dual low-expression （P 〈 0.05）. Multivariate analysis indicated that both Survivin and VEGF over-expressions in squamous carcinoma of larynx peripheral blood samples were strong independent factors of poor prognosis in squamous carcinoma of larynx patients. Conclusion： Survivin and VEGF over-expressions are independent prognostic factors for the patients with squamous carcinoma of larynx. These results also suggest that peripheral blood Survivin and VEGF expressions are valuable prognostic markers for prognosis prediction in squamous carcinoma of larynx patients.

关 键 词：squamous carcinoma of larynx SURVIVIN VEGF 

分 类 号：R730[医药卫生—肿瘤]