影响妊娠合并重型肝炎预后的单因素研究  

Univariate analysis on the prognosis of pregnancy complicating fulminant hepatitis

作　　者：李小毛[1] 邓柳枝[1] 陈敦金[2] 余艳红[3] 唐小平[4] 赵少飞[5] 谭华霖 

机构地区：[1]中山大学附属第三医院妇产科,广州510630 [2]广州医学院第三附属医院重症孕产妇救治中心,广州510150 [3]南方医科大学南方医院,广州510515 [4]广东省广州市第八人民医院,510060 [5]广东省妇幼保健院,广州510010 [6]广东省广州市番禺区何贤纪念医院,511400

出　　处：《广东医学》2008年第11期1806-1808,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2005B340201006);广东省中医药管理局科研基金资助项目(编号:1060166)

摘　　要：目的分析影响妊娠合并重型肝炎预后的单因素。方法对66例妊娠合并重型肝炎患者预后的单因素进行回顾性分析。结果①不同临床分型的病死率不同,急性型最高,慢性型最低;②Tch、PTA降低、Scr升高及WBC≥10×109/L、"胆酶分离"现象、肝脏缩小均提示病死率升高;③随着肝性脑病、肝肾综合征、出血、感染等并发症的增多,病死率升高,以上差异均有统计学意义。结论临床分型、Tch、PTA、Scr、WBC、"胆酶分离"现象、肝脏缩小及并发症等是影响妊娠合并重型肝炎预后的重要因素,动态监测上述指标,积极防治各类并发症是提高临床救治成功率的重要措施。Objective To analyze factors predicting the prognosis of patients with pregnancy complicating fulminant hepatitis. Methods Univariate analysis was performed retrospectively in 66 patients with pregnancy complicating fulminant hepatitis. Results ①Mortality was different among different types of clinical Classification, with highest mortality in acute hepatitis and lowest mortality in chornic hepatitis; ②Reduction in Tch and PTA, increase in Scr, WBC≥10 × 10^9/L, phenomenon of ＂bilirubin- transaminase separation＂ and shrinkage of liver were suggestive of elevated mortality; ③Mortality increase with the complications such as hepatic eneephalopathy, hepatorenal syndrome, hemorrhage and infection. The differences of above indexes were all statistically significant. Conclusion Clinical Classification, Tch, PTA, Scr, WBC, phenomenon of ＂bilirubin - transaminase separation＂, shrinkage of liver and complications are important factors influencing the prognosis of patients with pregnancy complicating fulminant hepatitis, dynamic monitoring of such indexes and aggressive prevention and treatment of complications are important measures to improve clinical outcome.

关 键 词：妊娠 重型肝炎 预后 单因素 

分 类 号：R575[医药卫生—消化系统] R195.1[医药卫生—内科学]