B_7分子在肿瘤免疫应答中作用的研究  

Study on the Effect of B_7 Mlecule in Antitumor Immunoresponce

作　　者：邵启祥[1] 许化溪 严俊[1] 马宝骊[1] 

机构地区：[1]上海第二医科大学免疫学教研室

出　　处：《镇江医学院学报》1997年第4期387-388,共2页Journal of Zhenjiang Medical College

摘　　要：将用B7基因转化的和未转化的人乳腺癌细胞B7-MDA453和MDA453经丝裂霉素处理后，给大鼠尾静脉注射1×107细胞连续3天．3天后取大鼠脾脏细胞在外体进行CTL细胞毒试验、MLC和ConA刺激的脾细胞增殖试验。结果证明．经B7－MDA453处理的大鼠所引发的CTL细胞毒作用、MLC和ConA刺激的脾细胞增植试验明显较MDA453处理组高，说B7分子在肿瘤免疫应答中发挥了重要作用。After cultured with mitomycin C, the B7gene transfected and no-transfected breast cancercell line B7-MDA453and MDA453 were injected iuto rat vein, there were 1×107 cell/d injected forthree days. Then were the splenocytes CTL cytotoxicity, MLC and the proliferation of lympbocytes afterstimulated by ConA. The results expressed that CTL cytotoxicity, MLC and ConA stimulted lymphocytesproliferation of the B7-MDA453 injection group were higher than tbe MDA453 injection group. Hencethe B7 molecule has the important role iu the antitumor immunoresponse.

关 键 词：B7分子 肿瘤 免疫应答 肿瘤细胞 

分 类 号：R730.3[医药卫生—肿瘤]