p57^kip2和p21^cip1在人脑胶质瘤中的表达和临床意义  

Expressions of p57^(kip2) and p21^(cip1) in human glioma and their clinical significance

作　　者：杨涛[1,2] 张熙[1] 周乐[1] 屈建强[1] 

机构地区：[1]西安交通大学医学院第二附属医院神经外科,陕西西安710004 [2]安康职业技术学院附属医院神经外科,陕西安康725000

出　　处：《西安交通大学学报（医学版）》2008年第5期562-565,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科技计划基金资助项目(No.2006K09-G2(12))

摘　　要：目的探讨p57kip2蛋白、p21cip1蛋白在人脑胶质瘤中的表达情况及其临床意义。方法采用免疫组织化学SP法检测p57kip2、p21cip1在55例人脑胶质瘤和10例正常脑组织中的表达。结果在55例胶质瘤中,p57kip2蛋白阳性率为38.2%(21/55),显著低于正常脑组织的80%(8/10)(P=0.036)。p57kip2蛋白表达在低度恶性(Ⅰ-Ⅱ级)组显著高于高度恶性(Ⅲ-Ⅳ级)组(P=0.029),生存时间≥2年组显著高于<2年组(P=0.032)。脑胶质瘤中p21cip1蛋白阳性率为60.0%(33/55),与正常脑组织的90.0%(9/10)相比,差异无统计学意义(P=0.143)。p21cip1蛋白表达在高度恶性(Ⅲ-Ⅳ级)组显著低于低度恶性(Ⅰ-Ⅱ级)组(P=0.047),生存时间<2年组显著低于≥2年组(P=0.002)。p57kip2蛋白的表达与p21cip1蛋白的表达存在正相关(rs=0.354,P=0.008)。结论p57kip2蛋白和p21cip1蛋白在脑胶质瘤中存在异常表达,p57kip2蛋白和p21cip1蛋白的表达程度与脑胶质瘤的分化程度、预后相关。Objective To explore the expressions of p57 ^kip2 and p21^cip1 in human gliomas and their clinical significance.Methods P57^kip2 and p21^cip1 were detected by SP immunohistochemical technique in 55 human glioma and 10 normal brain tissues.Results Expression rate of p57^kip2 protein in human glioma was 38.2%（21/55）,which was significantly lower than that in normal brain tissues 80%（8/10）（P =0.036）.P57^kip2 expression in low malignance group（Ⅰ-Ⅱ grade） was significantly higher than that in high malignance group（Ⅲ-Ⅳ grade）（P =0.029） and in survival time ≥2 years group was significantly higher than that in 〈2 years group（P =0.032）.Expression rate of p21^cip1 protein in human glioma was 60.0 %（33/55）,not significantly lower than that in normal brain tissues 90.0%（9/10）（P =0.143）.p21^cip1 expression in high malignance group（Ⅲ-Ⅳ grade） was significantly lower than that in low malignance group（Ⅰ-Ⅱ grade）（P =0.047） and in survival time〈2 years group was significantly lower than that in ≥2 years group（P =0.002）.There was a positive correlation between the expression of p57^kip2 and p21^cip1（r s =0.354,P =0.008）. Conclusion The expression of p57^kip2 protein and p21^cip1 protein is deregulated in glioma,and its degree is correlated with the glioma differentiation and prognosis.The combined analysis of p57^kip2 and p21^cip1 expression is considered to be more reliable.

关 键 词：P57^KIP2蛋白 p21^cip1蛋白 胶质瘤 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]