HBsAg阳性原发性肝癌根治术后血清HBV DNA水平对肝癌复发的影响  

Postoperative Serum HBVDNA Level Evaluate the Recurrence after Radical Resection for Patients with HBV-Related Hepatocellular Carcinoma

作　　者：蔡欣然[1] 黄长玉[1] 周浩辉[1] 周良艺[1] 

机构地区：[1]福建医科大学附属协和医院肝胆外科,福州350001

出　　处：《福建医科大学学报》2008年第5期438-440,共3页Journal of Fujian Medical University

基　　金：福建省自然科学基金计划资助项目(C0310020)

摘　　要：目的探讨HBsAg阳性原发性肝癌根治切除术后血清HBV DNA水平对肝癌复发的影响。方法HBsAg阳性原发性肝癌72例行根治性切除并经病理证实,检测术后1,3,6月血清HBV DNA水平、肝功能、复发时间与临床病理资料,行并统计学分析。结果术后不同时期血清HBV DNA水平变化差别无统计学意义(P>0.05);HBV DNA高水平、低水平、阴性组的术后2年复发率和中位复发时间分别为70%、45.57%、36.36%和14、34、41月,高水平与低水平、阴性组比较差别均有显著性统计学意义(P<0.01);多因素COX回归分析肝癌术后复发危险因素为门静脉分支癌栓、血清HBV DNA水平和肿瘤分化程度(P<0.05)。结论肝癌根治术后血清HBV DNA持续高水平是肝癌术后复发的危险因素。Objective To investigate the effect of the postoperative serum HBVDNA level on recurrence after radical resection for patients with HBsAg positive hepatocellular carcinoma. Methods 72 patients who underwent liver resection for HCC and were confirmed by pathology were studied. The serum HBV DNA level of postoperative 1,3,6 months were detected, and their clinical and pathologic findings, recurrence time, laboratory data were evaluated for recurrence risk in univariate and multivariate a- nalysis. Results 1. The serum HBV DNA level after liver tumor resection was not significantly differ- ence. 2.2-years recurrence rate and the median recurrence time in high HBV DNA level, low level and negative group were 70%, 45.57%, 36. 36% and 14,34,41 months, there was significantly different between high level and low level.negative group. Multivariate COX regression showed that the portal vein tumor thrombi.serum HBVDNA level and tumor differetiation were risk factors for HCC recurrence. Conclusion The high level of serum HBVDNA after radical resection for HCC may to be a risk factor for recurrence and a useful marker for predicting progonosis.

关 键 词：肝肿瘤 DNA 病毒 肝炎病毒 乙型 肝炎表面抗原 乙型 肿瘤复发 局部 

分 类 号：R735.705.3[医药卫生—肿瘤]