MUC2、CDX2在大肠肿瘤中联合表达的意义  

Expression and Clinical Significance of MUC2,CDX2 in Colorectal Neoplasm

作　　者：于秀文[1] 王显艳[1] 孙玉荣[1] 徐广有[1] 张晓杰[1] 

机构地区：[1]黑龙江省齐齐哈尔医学院病理教研室,161042

出　　处：《肿瘤防治研究》2008年第10期715-719,共5页Cancer Research on Prevention and Treatment

基　　金：黑龙江省教育厅科学技术研究项目资助(10551348)

摘　　要：目的探讨粘蛋白MUC2、CDX2在大肠腺癌中的分型及其与临床各个病理因素之间的关系。方法应用免疫组织化学方法对30例大肠腺瘤、60例大肠腺癌及相应正常大肠黏膜30例进行粘蛋白MUC2、CDX2检测。结果在大肠正常黏膜、腺瘤、腺癌中,MUC2阳性率分别为100%、93.3%、58.3%;CDX2为90.0%、76.7%、31.7%。根据MUC2和CDX2在大肠腺癌中的表达把大肠腺癌分为四型:MUC2+CDX2+、MUC2+CDX2-、MUC2-CDX2+、MUC2-CDX2-,MUC2+CDX2+型与分化程度、浸润深度、Dukes分期以及生存期相关;MUC2+CDX2-型与淋巴结转移相关;MUC2-CDX2+与临床病理因素不相关;MUC2-CDX2-型与分化程度、浸润深度、淋巴结转移、Dukes分期以及生存期具有明显的相关性。结论MUC2、CDX2的下调表达可能参与了大肠腺癌的发生,MUC2+CDX2+、MUC2-CDX2-型大肠腺癌与肿瘤的发生、发展、浸润及转移相关,对临床上判断预后具有较大的意义。Objective To investigate the relation between the classification of MUC2 and CDX2 in colorectal ad and its clinical pathological parameters. Methods The expression of MUC2 and CDX2 was detected by immunohistochemistry in 30 specimens of colorectal adenoma, 60 specimens of colorectal adenocarcinoma and 30 specimens of normal colorectal tissues. Results The positive rates of MUC2 in normal colorectal mucosa,colorectal adenoma and colorectal adenocarcinoma were 100%, 93. 3%, 58. 3% respectively. CDX2 were 90. 0% ,76. 7% ,31.7%. Colorectal adenocarcinoma could be classified into four phenotypes： MUC2 ＋ CDX2 ＋, MUC2 ＋ CDX2 -, MUC2 - CDX2 ＋, MUC2 - CDX2 -. MUC2 ＋ CDX2 ＋ showed significant corrdation with differentiation, depth of invasion, Dukes staging and survival period. MUC2 ＋ CDX2 - showed significant correlation with lymph node metastasis. MUC2 - CDX2 ＋ showed no significance in relation to all the clinical pathological parameters. MUC2 - CDX2 - showed significant correlation with differentiation, depth of invasion, lymph node metastasis, Dukes staging and survival period. Conclusion The dawn-regulation of MUC2 and CDX2 may participate in the pathogenesis of colorectal adenocarcinoma Classification of colorectal adenocarcinoma is relevant to the genesis, progression, invasion and metastasis of colorectal adenocarcinoma. , which can be used to predict the patients＇ prognosis.

关 键 词：大肠肿瘤 MUC2 CDX2 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]