透明质酸钠治疗颞下颌关节骨关节病的临床研究  

Clinical Study of Sodium Hyaluronate Acid Injection for Treatment of Temporomandibular Joint Osteoarthrosis

作　　者：秦霞南[1] 龙星[2] 李金荣[2] 

机构地区：[1]深圳市中医院第一门诊部口腔科,广东深圳518033 [2]武汉大学口腔医学院口腔颌面外科

出　　处：《口腔医学研究》2008年第5期548-550,共3页Journal of Oral Science Research

基　　金：深圳市科技局资助课题(编号:200602105)

摘　　要：目的：探讨透明质酸钠（Hyaluronate acid,HA）关节腔注射治疗骨关节病的临床效果。方法：选取经过颞下颌关节门诊治疗的早期OA患者20例行关节腔透明质酸钠注射治疗。20例患者中,男性8例,女性12例,年龄从16-68岁,平均年龄35.8岁。所有患者均进行颞下颌关节Fricton指数评价,进行术前及术后评分,并对所有患者术前进行颞下颌关节经颅侧位片及关节造影检查,治疗后6个月、12个月再进行侧位平片检查。结果：20例经HA治疗的早期OA患者,治疗前功能障碍指数0.358,治疗后功能障碍指数0.144,经统计学处理,有统计学意义（P〈0.05）;治疗前疼痛指数5.96,治疗后疼痛指数1.62,经统计学处理,有统计学意义（P〈0.05）。X线检查表明治疗前后关节间隙、骨质破坏等方面有明显好转。结论：HA关节腔注射能够有效地减轻早期OA患者的临床症状,阻止OA的进展,使其进入修复稳定期。Objective： To evaluate the efficacy of sodium hyaluronate acid（HA） injection for treatment of temporomandibular joint osteoarthrosis（OA）. Methods： 20 patients with OA were treated by TMJ injection of HA, who aged from 16 years to 69 years with an average age of 35.8 years. All patients were injected HA lml into TMJ weekly for 3 weeks. Before treatment, all patients were evaluated by fricton dysfunction index; then, 6 months after the last injection, all patients were evaluated by Fricton dysfunction index again. Radiographic examination was carried out before treatment and 6 months, 12 months after treatment. Results ： The mean scores of Fricton dysfunction index were 0. 358 and 0. 144 pre - treatment and post- treatment respectively. There was a significantly statistical difference between them（P 〈0.05）. The mean scores of pain index （visual analog variables, VAS） were 5.96 and 1.62 respectively. There was a significant difference between them（P 〈 0.05）. In addition, 6 patients radiographically exhibited bony changes after treatment. Conclusion： It is effective for the treatment of OA by using TMJ injection of HA.

关 键 词：颞下颌关节 骨关节病 透明质酸钠 治疗 

分 类 号：R782.6[医药卫生—口腔医学]