胃黏膜相关淋巴组织淋巴瘤PCNA和Survivin表达及其临床意义的研究  

Expressions of PCNA and Survivin in gastric lymphoma of mucosa-associated lymphoid tissue and their significance

作　　者：李少梅[1] 于玲[1] 姜慧峰[1] 

机构地区：[1]烟台市莱阳中心医院肿瘤科,山东莱阳265200

出　　处：《中华肿瘤防治杂志》2008年第17期1322-1324,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨PCNA、Survivin在胃相关淋巴组织(mucosa-associated lymph-oid tissue,MALT)淋巴瘤中的表达及其在肿瘤发生、发展中的意义。方法:应用免疫组织化学SP法对46例胃黏膜MALT淋巴瘤进行PCNA、Survivin标记。结果:在淋巴结有转移组与无转移组Survivin阳性率分别为83.3%和35.7%,差异有统计学意义,χ2=5.101,P=0.022;在肿瘤局限于黏膜下层与浸润肌层两组间Survivin阳性率分别为55.0%和53.8%,差异无统计学意义,χ2=1.433,P=0.240;在不同的临床分期Ⅰ、Ⅱ与Ⅲ期Survivin阳性率分别为28.0%和76.2%,差异有统计学意义,χ2=3.481,P=0.042。PCNA的表达强度随着肿瘤恶性程度的增高而增强。结论:PCNA的表达程度与胃MALT淋巴瘤的侵袭性病程有关;Survivin核表达提示胃MALT淋巴瘤的侵袭性增强。OBJECTIVE： To investigate the expressions of PC- NA and Survivin in gastro mucosa-associated lymphoid tissue （MALT） lymphoma, and their significance in the pathogenesis. METHODS： The expressions of PCNA and Survivin were assessed by the SP immunohistochemical test in 46 cases of gastric MALT. RESULTS： There were statistically significant differences in positive rate of Survivin between the lymph node positive group （83.3%） and lymph node negative group （35.7%）, χ^2=5.101,P=0. 022. There was no statistically significant difference between the group of limiting to the mucosa or submucosa （55.0%） and the group of immergingto muscularis propria （53.8%）, χ^21.433, P=0.240. The positive rate of Survivin in Stage Ⅰ , Ⅱ and Stage Ⅲ were 28.0% and 76.2%, respectively. There were significant differences between different clinical stages in Survivin expression, χ^2 = 3. 481, P 0. 042. PCNA positive expression increased with the increase of the degree of maliganancy. CONCLUSIONS： There is a positive correlation between PCNA positive expression and degree of aggressive course of gastric MALT. The Survivin positive staining suggests that the invasiveness of mucosa-associated lymphoid tissue （MALT） lymphoma will be significantly increased.

关 键 词：胃黏膜 淋巴组织 淋巴瘤 增殖细胞核抗原 

分 类 号：R735.2[医药卫生—肿瘤]