乙型肝炎病毒感染与原发性肝癌相关的危险度分析  

Risk analysis of hepatocellular carcinoma in people with hepatitis B virus infection

作　　者：苏洪英[1] 刘静[1] 何苗[1] 贾志芳[2] 关舒[2] 周宝森[2] 徐克[1] 

机构地区：[1]中国医科大学第一附属医院放射科,辽宁沈阳110001 [2]中国医科大学流行病学教研室,辽宁沈阳110001

出　　处：《中华肿瘤防治杂志》2008年第18期1368-1370,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的：分析原发性肝癌（PHC）患者血清中乙型肝炎病毒（HBV）标志情况,探讨HBV感染与PHC危险性的关系。方法：收集在中国医科大学附属第一医院介入科住院的PHC患者224例作为病例组,同时期在此科住院的其他非肝病患者280例作为对照组,记录其血清HBV标志,与既往乙型肝炎和肝硬化等情况进行病例对照研究。结果：PHC组HBV总感染率为68.22%（146/214）,以HBsAg阳性（65.42%,140/214）和抗-HBe阳性（30.84%,66/214）为主,对照组总感染率为7.63%（20/262）,其中以HBsAg（3.44%,9/262）和抗-HBe（7.63%,20/262）为主。病例组感染率明显高于对照组（χ^2=200.1,P〈0.000 1）,优势比OR=27.4（95%CI为16.0～46.9）。结论：HBV慢性感染是PHC的一个危险因素,在HBV慢性感染者中进行PHC筛查,对早期诊断PHC提高其临床疗效有重要意义。OBJECTIVE： To study the relationship between hepatocellular carcinoma and hepatitis B virus by reviewing the level of serum markers of hepatitis B virus in hepatocellular carcinoma cases and other cases without liver diseases.METHODS：The cases of hepatocellular carcinoma（224） and non-liver diseases（280） were sampled hospitalized in the First Affiliated Hospital of China Medical University.Then a case-control study was performed on serum markers of HBV and the history of hepatitis B,cirrhosis and so on of all the cases.RESULTS： The total infection rate of HBV in the heatocellular carcinoma cases was 68.22%（146/214） with 65.42%（140/214） of HBsAg and 30.84%（66/214） of anti-HBe,and 7.63%（20/262） in the non-liver disease cases.There was a significant difference（χ^2=200.1,P〈0.000 1） on the total infection of HBV between the hepatocellular carcinoma cases and the controls,and the relative risk calculated was 27.4（95%CI 16.0-46.9）.CONCLUSION： HBV is a major risk factor for hepatocellular carcinoma and PHC screening for people with HBV infection plays an important role in the PHC early diagnosis and improving therapeutic effect.

关 键 词：肝肿瘤 肝炎病毒 乙型 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]