α1,3岩藻糖基转移酶Ⅶ和糖蛋白CD24与肿瘤转移的研究进展  

Advance in the study of α1,3 fucosyltransferase Ⅶ and glycoprotein CD24 in tumor metastasis

作　　者：李文桦[1] 张文[2] 

机构地区：[1]复旦大学附属肿瘤医院肿瘤内科 [2]复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国癌症杂志》2008年第10期790-795,共6页China Oncology

摘　　要：肿瘤复发转移是癌症患者死亡的主要原因。异常糖基化是恶性肿瘤转移的重要机制之一。糖蛋白CD24和多种肿瘤转移相关,它可介导癌细胞和血小板结合,促进肿瘤转移,但具体机制尚不清楚。α1,3岩藻糖基转移酶Ⅶ(FucT-Ⅶ)是一种与肿瘤转移相关的糖链加工酶,作用于糖蛋白、寡糖和糖脂,研究表明其糖基化产物唾液酸化的LewisX(SLeX)在肿瘤中高表达并对CD24的功能起重要作用。FucT-Ⅶ是否通过促进CD24糖基化从而在肿瘤转移中起关键作用让人期待。Tumor recurrence and metastasis are the major cause for cancer patient death. Aberrant glycosylation is one of the important mechanisms of malignant tumor metastasis. The glycoprotein CD24, which could be a ligand for P-selectin on the surface of activated endothelial cells and platelets, appears to be a new diagnostic marker of tumors and possibly participates in tumor metastasis with unknown pathway. α1,3 Fucosyltransferase Ⅶ （FucT-Ⅶ） is one of the fucosyltransferases which catalyze the transfer of a fucosyl residue from GDP-α-L-fucose to a sugar acceptor, usually galactose in the sugar chains of glycoproteins or glycolipids. The elevated expression of sialyl Lewis （SLe^X）, the only carbohydrate product of α1,3 FucT-Ⅶ , predicts an ominous prognosis and high risk of recurrence and regulates the function of CD24. It is possible that α1,3 FucT-Ⅶ may enhance the glycosylation of CD24 and thus promote the tumor metastasis.

关 键 词：FucT-Ⅶ CD24 岩藻糖基化 肿瘤转移 

分 类 号：R73-37[医药卫生—肿瘤]