血浆同型半胱氨酸浓度与短暂性脑缺血发作的关系  

Correlation Between Plasma Homocysteine Concentration and Transient Ischemic Attack

作　　者：肖佩荣[1] 钟建国[1] 侍海存[1] 王瑶[1] 宋维庚[1] 周桂龙[1] 沈媛[1] 孙晟[1] 王根娣[1] 

机构地区：[1]东南大学医学院附属盐城医院神经内科,盐城 224001

出　　处：《国际脑血管病杂志》2008年第9期690-693,共4页International Journal of Cerebrovascular Diseases

摘　　要：目的：探讨血浆同型半胱氨酸（Hcy）浓度与短暂性脑缺血发作（TIA）及传统血管危险因素的关系。方法：采用荧光偏振免疫分析法测定112例TIA患者和62例对照者的血浆Hcy浓度，分析Hcy浓度及相关危险因素。结果：与血浆Hcy浓度〈10．0μmol／L组相比，血浆Hcy浓度10．0～14．9μmol／L组（OR=2．450，95％CI1．091～5．502）和≥15．0μmol／L组（OR=5．169，95％CI2．096～12．746）的TIA风险显著增高。将TIA作为应变量，各种血管危险因素（包括Hcy浓度）作为自变量，进行logistic回归分析，结果显示，与血浆Hcy浓度〈10．0μmol／L组相比，血浆Hcy浓度〉10．0μmol／L组TIA风险显著增高（OR=3．150，95％CI1．380～7．192）。结论：血浆Hcy浓度是TIA的独立危险因素。Objective： To investigate the correlation between plasma homocysteine （Hcy） concentration and transient ischemic attack （TIA） and traditional vascular risk factors. Methods： The plasma Hcy concentrations of 112 patients with TIA and 62 contols were measured by fluorescenee polarization immunoassay. Hcy concentrations and related risk factors were analyzed. Results： The risk of TIA was increased significantly in plasma Hcy concentration 10.0 to 14. 9 μmol/L group （OR=2. 450, 95% CI 1. 091 to 5. 502） and 〉115.0 μmol/L group （OR = 5. 169, 95% CI 2. 096 to 12. 746） compared with plasma Hcy concentration 〈 10. 0 μmol/L group. Using TIA as the dependent variable, various vascular risk factors （including plasma Hcy concentration） as the independent variable, logistic regression was analyzed, the result showed that the risk of TIA was increased significantly in plasma Hcy concentration 〉 10. 0 μmol/L group compared with plasma Hcy concentration 〈10. 0 μmol/L group （OR=3. 150, 95% CI 1. 380 to 7. 192）. Conclusions： Plasma Hcy concentration is an independent risk factor for TIA,

关 键 词：短暂性脑缺血发作 同型半胱氨酸 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]