原发性中枢神经系统血管内恶性淋巴瘤1例报告并文献复习  

Primary Intravascular Malignant Lymphomatosis Angiotropic BCell Lymphomas in Central Nervous System:A Case Report and Literature Review

作　　者：李成义[1] 高峰[1] 刘宗明[1] 饶芝国[1] 伊志强[1] 

机构地区：[1]北京大学航天临床医学院神经外科,北京100049

出　　处：《中国误诊学杂志》2008年第35期8575-8578,共4页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨原发性中枢神经系统血管内恶性淋巴瘤(IM L)的诊治规律。方法:报告并结合文献复习,分析1例IM L临床表现、影像学特征和病理学特点。结果:本病呈亚急性病程,多发性缺血性梗塞病灶合并中心灶性出血,始终无强化。病理示广泛血管内恶性B淋巴瘤细胞大量增殖,导致血管堵塞,免疫组化LCA、CD 20阳性,CD 45RO阴性。结论:IM L是一种罕见的系统性播散性、高级别的非霍奇金淋巴瘤,临床表现及影像学征象缺乏特异性。其预后不良,平均生存期<1 a。Objective：To review and explore the diagnosis and therapeusis of primary intravascular lymphomatosis of central nervous system. Methods：Clinical manifestations ,image and histopathology characteristics were analyzed and the related literatures were reviewed. Results ： This patient underwent a subacute course of encephalopathy. The images illustrated multifocal ischemic lesions with hemorrhagic central lesion,and without enhancement. The pathological findings were extensive intravascular proliferation of neoplastic lymphocytes B and consequent cerebrovascular occlusion. The immunohistochemistry findings ： LCA （ ＋ ）, CD20 （ ＋ ）, CD45RO （ - ）. Conclusions ： Intravascular malignant lymphomatosis is an exceptional and disseminated high ranking non-Hodgkin lymphoma without specific clinical manifestation and image charateristics,and its prognosis is unfavourable with the mean survival time less than one year.

关 键 词：中枢神经系统肿瘤 淋巴瘤 非霍奇金 病例报告[文献类型] 人类 

分 类 号：R733.41[医药卫生—肿瘤]