肠易激综合征的中医虚实证型与血浆脑肠肽水平变化的相关性研究  

Correlation between TCM deficiency and excess syndrome and plasma brain-gut peptides levels in patients with irritable bowel syndrome

作　　者：常东[1] 樊亚巍[1] 陶永胜[1] 李辉[1] 何方[1] 张东坡[2] 

机构地区：[1]武警广东省边防总队医院军人治疗中心,广东深圳518029 [2]深圳市中医院第一门诊部,广东深圳518033

出　　处：《中国中西医结合消化杂志》2008年第5期299-301,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：深圳市2006年科技计划项目(200602149)

摘　　要：[目的]观察肝郁气滞型、脾胃虚弱型、肝郁脾虚型肠易激综合征(IBS)患者脑肠肽的变化,探讨IBS的中医虚实证型与血浆脑肠肽水平变化的相关性。[方法]90例IBS患者分为肝气郁滞证组、肝郁脾虚证组、脾胃虚弱证组各30例,正常对照(正常)组10例,应用放射免疫法同批测定血浆血管活性肠肽(VIP)、神经肽Y(NPY)和神经降压素(NT)水平。[结果]3个证型组患者血浆VIP水平显著高于正常组(P<0.05,<0.01);脾胃虚弱、肝郁脾虚证组患者VIP水平显著高于肝气郁滞证组(P<0.05),但脾胃虚弱证组和肝郁脾虚证组之间比较差异无统计学意义。3个证型组患者血浆NPY水平显著低于正常组(P<0.05,<0.01),肝郁脾虚证组和肝气郁滞证组NPY水平明显低于脾胃虚弱证组(P<0.01,<0.05),肝郁脾虚证组NPY水平低于肝气郁滞证组,但2组比较差异无统计学意义。3个证型组患者血浆NT水平显著高于正常组(P<0.01)。3证型间比较差异无统计学意义。[结论]不同中医证型IBS脑肠肽存在不同的变化。IBS的中医病机观与现代医学所倡导的脑-肠轴学说具有相关性。[Objective]To observe the change of the plasma brain-gut peptides levels about syndrome type of stagnation of qi due to depression of the liver, spleen stomach deficiency and liver-qi stagnation and spleen-qi deficiency in patients with irritable bowel syndrome（IBS）, and to probe into the correlation correlation between TCM fullness and deficiency syndrome type of and plasma brain-gut peptides levels. [Methods]Ninety cases of patients with IBS were derided into stagnation of qi due to depression of the liver group（30 cases）, spleen stomach deficiency group（30 cases） and liver-qi stagnation and spleen-qi deficiency grope（30 cases）, with normal group（10 cases） as controls. It is determined by radioimmunoassay about expressions of plasma vasoactive intestinal peptide（VIP）, neuropeptide Y（NPY） and neurotensin（NT）, [Results]The plasmal level of VIP was significantly higher in three syndrome type groups patients than that in the normal controls（P〈0. 05 P〈0. 01）. The plasmal level of VIP in spleen stomach deficiency and liver-qi stagnation and spleen-qi deficiency syndrome type groups was significantly higher than that in stagnation of qi due to depression of the liver syndrome type group（P〈0. 05）. The plasmal level of NPY was significantly lower in three syndrome type groups patients than that in the normal controis（P〈0. 05,P〈0. 01）. The plasmal level of NPY in liver-qi stagnation and spleen-qi deficiency and stagnation of qi due to depression of the liver syndrome type was significantly lower than that in the spleen stomach deficiency syndrome type（P〈0. 01, P〈0. 05）. The plasmal level of NT was significantly higher in three syndrome type groups patients than that in the normal controis（P〈0.01）. [Conclusion]Plasma brain-gut peptides levels in patients with IBS may be related to different TCM syndrome type. There is a correlation between the TCM patbogenesis theory about IBS and the brain-gut axle theory.

关 键 词：肠易激综合征 辨证分型 脑肠肽 

分 类 号：R57[医药卫生—消化系统] R241[医药卫生—内科学]