鲜葛花汁对大鼠急性酒精性肝损伤的保护作用  

Protective effect of gehua fresh juice on rats with acute hepatic damage caused by alcohol

作　　者：侯光华[1] 张介眉[2] 时昭红[2] 张晶[3] 郝建军[2] 陈洲[1] 

机构地区：[1]湖北中医学院中医系,湖北武汉430061 [2]武汉市第一医院消化内科,湖北武汉430022 [3]武汉科技大学附属医院急诊科,湖北武汉430081

出　　处：《中国中西医结合消化杂志》2008年第5期315-318,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：武汉市卫生局临床科研课题资助项目(WZ08A01)

摘　　要：[目的]观察鲜葛花汁对大鼠急性酒精性肝损伤的预防保护作用。[方法]以单味葛花汤、益肝灵为对照,各组大鼠均先给予相应的药物灌胃,0.5 h后以白酒灌胃造成急性酒精性肝损伤模型,每天2次,连续灌胃7 d,第7天处死全部大鼠,检测血清和肝组织丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST),同时光镜观察肝组织病理形态学的改变。[结果]鲜葛花汁能有效降低急性酒精性肝损伤模型大鼠血清及肝组织ALT、AST的升高,且作用显著优于对照组(P<0.01);同时对大鼠肝组织病理形态学改变具有明显改善作用。[结论]鲜葛花汁可用于治疗酒精及其他原因引起的肝损伤。[Objective]To explore the protective effect of gehua fresh juice on rats with acute hepatic damage caused by alcohol. [Methods]Compared with single gehua decoction and Yiganling, all of rats were first perfused with corresponding drugs, and then perfused with white wine to cause acute alcoholic liver damage. On the 7^th day rats were sacrificed completely, and ALT, AST in sera and tissues were assayed. Simultaneously pathologic change of liver were examined. [Results] Gehua fresh juice could effectively inhibit the elevation of ALT and AST in acute alcoholic hepatic damage, which is superior to the control groups（P〈0. 01）; it also could significantly ameliorate the damages of liver tissue. [Conclusion]Gehua fresh juice may be recommended for treating hepatic damage caused by alcoholism and other causes.

关 键 词：鲜葛花汁 肝损伤 急性酒精性 肝组织 

分 类 号：R573[医药卫生—消化系统]