FBT预处理方案异基因外周血造血干细胞移植治疗难治／复发急性非淋巴细胞白血病  

Allogeneic hematopoietic stem cell transplantation using Flu/ivBu/TT conditioning regimen for refractory or relapsed acute nonlymphocytic leukemia

作　　者：王三斌[1] 胡灯明[1] 彭利晖[1] 刘林[1] 谢政军[1] 尹波[1] 孙晓娟[1] 

机构地区：[1]成都军区昆明总医院血液科,云南昆明650032

出　　处：《中国医师杂志》2008年第10期1300-1302,共3页Journal of Chinese Physician

基　　金：成都军区医学科研计划课题资助项目资助项目（MB07027）

摘　　要：目的探讨以氟达拉滨＋白舒非＋噻替哌作为预处理方案（FBT预处理方案），进行异基因外周血造血干细胞移植治疗难治／复发急性非淋巴细胞白血病的疗效及可行性。方法以FBT方案作为预处理方案，以环孢素A＋骁悉预防移植物抗宿主病（GVHD），对7例难治／复发急性非淋巴细胞白血病患者进行HLA全相合异基因外周血造血干细胞移植。结果中位随访时间31个月，2例复发，5例患者无病存活。结论FBT预处理方案复发率低，毒副作用轻，相关并发症少，患者耐受性好，对于难治／复发急性非淋巴细胞白血病患者而言，是一种值得进一步探讨的临床治疗方案。Objective To evaluate the efficacy and feasibility of Flu/ivBu/TT conditioning regimen for the treatment of refraetory or relapsed acute non-lymphocytic leukemia in patients receiving allogeneic hematopoietic stem cell transplantation. Methods Seven patients with refractory or relapsed acute non-lymphocytic leukemia received HLA identical peripheral blood hematopoietic stem cell transplantation （PBSCT） following Flu/ivBu/TT conditioning regimen, which consisted of fludarbine, busulfex and thiotepa. All patients received cyclosporin A （CsA） and mycophenolet mofetil （MMF） for prophylaxis of graft - versus - host disease （GVHD）. Results The Flu/IVBu/TT regimen was tolerated very well, without severe regimen related toxicity. In the 31-month median follow-up duration, 5 of 7 patients were alive in disease-free situation. Conclusion The Flu/ivBu/TT conditioning regimen reduced transplantation-related toxieities and offered high long-term disease-free survival, and was tolerated very well. Allogcneic hematopoietic stem cell transplantation using Flu/ivBu/TT conditioning regimen is a safe and effective option for the patients with refractory/relapsed acute non-lymphocytic ieukemia.

关 键 词：噻替派/治疗应用 白消安/治疗应用 阿糖腺苷/治疗应用/类似物和衍-生物 白血病 非淋巴细 胞 急性/预防和控制 移植预处理 造血干细胞移植 移植物抗宿主病 

分 类 号：R733[医药卫生—肿瘤]