自体骨髓单个核细胞移植治疗老年冠状动脉粥样硬化性心脏病的临床观察(英文)  

Autologous bone marrow mononuclear cell transplantation for treatment of coronary heart disease in the elderly

作　　者：徐予[1] 徐岩 高传玉[1] 王显沛[1] 陈岩[1] 翟亚萍[1] 

机构地区：[1]河南省人民医院心内科,河南省郑州市450003 [2]河南省直第一医院心内科,河南省郑州市450003

出　　处：《中国组织工程研究与临床康复》2008年第43期8575-8578,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：Supported by: the Science and Technology Innovation Talented Man Program of Henan Province, No. 2004081~~

摘　　要：2003-06/2007-11河南省人民医院心内科收治的老年心肌梗死患者76例,行骨髓干细胞移植患者46例,男34例,女12例,除常规治疗外,将骨髓单个核细胞悬液在冠状动脉造影时经导管注入冠状动脉内;未行骨髓干细胞移植患者30例为对照组,男22例,女8例,仅采用常规治疗。随访1年,经胸超声心动图显示,骨髓干细胞移植组和对照组左室射血分数分别由治疗前(43.1±5.6)%、(44.9±7.5)%增加到(54.8±4.6)%、(50.1±7.1)%;骨髓干细胞移植组和对照组脑钠肽水平由治疗前(696±102)、(680±93)ng/L下降至(303±89)、(396±88)ng/L;单光子放射计算机断层显像术显示,骨髓干细胞移植组和对照组心肌灌注缺损面积分别由(25.8±8.5)%、(26.2±6.4)%降低至(14.8±4.6)%、(20.4±7.3)%。骨髓干细胞移植组在移植过程中和移植后均无并发症发生。表明经皮冠状动脉内移植骨髓干细胞治疗老年心肌梗死患者安全可行,移植后能改善左室收缩功能及心肌血流灌注。Totally 76 elderly patients with myocardial infarction, who were treated at the Department of Cardiology, Henan People＇s Hospital, were enrolled from June 2003 to November 2007. Of them, 46 received bone marrow stem cell transplantation, including 34 males and 12 females. Except conventional treatment, bone marrow mononuclear cells were injected into the coronary artery via a catheter during coronary arteriography. Thirty who did not undergo bone marrow stem cell transplantation, including twenty-two males and eight females were only subjected to conventional treatment. After one-year follow-up, thoracal ultrasoundcardiogram showed left ventricular ejection fraction increased from （43.1±5.6）%, （44.9±7.5）% before treatment to （54.8±4.6）%, （50.1±7.1）% in the bone marrow stem cell transplantation and control groups. Levels of plasma brain natriuretic peptide decreased from （696±102）, （680±93） ng/L before treatment to （303±89）, （396±88） ng/L in the bone marrow stem cell transplantation and control groups. Single-photon-emission computed tomography demonstrated that the sizes of myocardial perfusion defect decreased from （25.8±8.5）%, （26.2±6.4）% to （14.8±4.6）%, （20.4±7.3）% in the bone marrow stem cell transplantation and control groups. No complication was detected during and after transplantation in the bone marrow stem cell transplantation group. Percutaneous transplantation of autologous bone marrow stem cells for treating elder patients with myocardial infarction is sate and feasible, which resulted in improvement in left ventricular systolic function and myocardial perfusion.

关 键 词：自体骨髓单个核细胞 老年 心肌梗死 左心室功能 

分 类 号：R394.2[医药卫生—医学遗传学]