EphA7在胰腺癌组织中的表达及意义  

The expression and significance of EphA7 in pancreatic carcinoma

作　　者：李德泉[1] 吴河水[1] 王琳[2] 王琳芳[3] 王春友[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院胰腺外科中心,武汉430022 [2]华中科技大学同济医学院附属协和医院儿科,武汉430022 [3]华中科技大学同济医学院附属协和医院急诊外科,武汉430022

出　　处：《中华胰腺病杂志》2008年第5期312-314,共3页Chinese Journal of Pancreatology

摘　　要：目的检测EphA7蛋白在胰腺癌组织中的表达，探讨其与胰腺癌发生发展的关系。方法应用免疫组化方法检测10例正常胰腺组织、51例胰腺癌及其配对癌旁组织中EphA7蛋白的表达，并分析其与胰腺癌病理参数的关系。结果正常胰腺组织、胰腺癌旁组织和胰腺癌组织中EphA7蛋白的阳性表达率分别为10％（1／10）、47．1％（24／51）和94．1％（48／51），差异有显著性统计学意义（P〈0．05）。EphA7蛋白高表达与胰腺癌患者的年龄、性别、肿瘤部位、肿瘤大小无关（P〉0．05），而与肿瘤分化程度、临床分期、淋巴结转移或远距转移密切相关（P〈0．05）。结论EphA7高表达可能与胰腺癌的发生、发展及转移有关。Objective To investigate the relationship between EphA7 protein and carcinogenesis and development of pancreatic cancer by detecting the expression of EphA7 protein in pancreatic cancer tissues. Methods The expression of EphA7 in 10 cases of normal pancreatic tissue, 51 cases of pancreatic cancer and its adjacent tissues were detected with immunohistochemical methods and the relationship between EphA7 and pathologic features of pancreatic cancer were analyzed. Results The rate of expression of EphA7 protein in normal pancreatic tissue was 10% （1/10）, 47.1% （24/51） in adjacent pancreatic cancer tissues, 94.1% （48/51） in pancreatic cancer tissues. There were significant difference among the three groups （P 〈 0.05 ）. There was no significant correlation between the expression of EphA7 protein and the age, sex, tumor location, tumor size in patients with pancreatic cancer （ P 〉 0.05 ）. However there was significant correlation between the expression of EphA7 protein and the degree of differentiation, clinical staging, lymph node metastasis, or distant metastasis （ P 〈 0.05 ）. Conclusions The abnormally high expression of EphA7 may be relevant with the occurrence and development of the pancreatic cancer.

关 键 词：胰腺肿瘤 蛋白质酪氨酸激酶 EPHA7 

分 类 号：R735.9[医药卫生—肿瘤]