肠道复合性弥漫性大B细胞淋巴瘤及周围T细胞淋巴瘤临床病理观察  

Intestinal composite diffuse large B-cell lymphoma and peripheral T-cell lymphoma:a clinicopathological observation

作　　者：水若鸿[1,2] 周晓燕[1,2] 罗国培[3] 陆洪芬[1,2] 许越香[1,2] 王懿龄[1,2] 朱雄增[1,2] 

机构地区：[1]复旦大学附属肿瘤医院病理科,上海200032 [2]复旦大学上海医学院肿瘤系,上海200032 [3]复旦大学附属华山医院普外科,上海200040

出　　处：《诊断病理学杂志》2008年第5期369-372,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨罕见的肠道复合性淋巴瘤的临床病理特征。方法采用形态学、免疫组化及分子遗传学方法对1例肠道复合性弥漫性大B细胞淋巴瘤及周围T细胞淋巴瘤进行临床病理分析并复习文献。结果本例肠道复合性B与T细胞淋巴瘤在形态上有弥漫性大B细胞淋巴瘤和非特殊性周围T细胞淋巴瘤的两种区域,免疫组化CD20和CD3(+),分子遗传学上同时有IgH和TCR基因重排。结论肠道复合性淋巴瘤罕见,诊断需结合形态、免疫表型和分子遗传学特征。Objective To introduce and discuss the clinicopathological features of a rare intestinal composite lymphoma. Methods A case of intestinal composite diffuse large B-cell lymphoma and peripheral T-cell lymphoma was studied by histopathology, immunohistochemistry and molecular genetics with review of the literatures. Results This case of intestinal composite B-and T-cell lymphoma had the area of diffuse large B-cell lymphoma and unspecified peripheral T-cell lymphoma, which expressed CD20 and CD3 separately. IgH and TCR gene rearrangements were also detected. Conclusion Intestinal composite lymphoma is a rare tumor. The diagnosis of intestinal composite lymphoma should be made with combination of morphology, immunophenotype and molecular genetics to avoid misdiagnosis.

关 键 词：复合性淋巴瘤 弥漫性大B细胞淋巴瘤 非特殊性周围T细胞淋巴瘤 肠道淋巴瘤 

分 类 号：R735.3[医药卫生—肿瘤]