甲状腺癌P_(53)基因的表达及意义  

THE EXPRESSION OF P53 GENE AND ITS SIGNIFICANCE IN THYROID CARCINOMA

作　　者：周青波[1,2] 王越先[1,2] 武彦[1,2] 托娅[1,2] 王玉芳[1,2] 冯海鸿 

机构地区：[1]内蒙古医学院病理解剖学教研室 [2]伊盟达拉特旗医院内科

出　　处：《内蒙古医学院学报》1997年第4期20-22,共3页Acta Academiae Medicinae Neimongol

摘　　要：为探讨Ｐ５３癌基因在人类甲状腺癌组织中的表达及意义，用免疫组化方法对１０３例甲状腺癌及伴乳头状增生的甲状腺腺瘤和结节性甲状腺肿进行研究。结果甲状腺未分化癌和发生淋巴结转移的分化型甲状腺癌，Ｐ５３基因的阳性表达率均为６３．６％。无淋巴结转移的乳头状癌和滤泡癌Ｐ５３基因阳性表达率分别为２０８％和１０％。伴乳头状增生的甲状腺腺瘤和结节性甲状腺肿Ｐ５３蛋白仅有微弱表达。未分化甲状腺癌与分化型甲状腺癌；有淋巴结转移的甲状腺癌与无淋巴结转移的甲状腺癌之间有非常显著的差异，Ｐ＜００１。甲状腺癌中Ｐ５３基因的过度表达可作为甲状腺癌分化程度，潜在淋巴结转移和预后的评估指标。To explore the expression and significance of P53oncogene in thyroid carcinoma, 103 cases of thyroid tumor and hyperplasia diseases, including thyroid carcinoma, thyroid adenoma with papillary hyperplasia and goiter with nodular changes, were investigated by immunohistochemical method. Results showed that expression rate of P53 gene was 63.6% in undifferentiated thyriod carcinoma and those differentiated with lymph node metastasis. The expression rate of P53 gene in differentiated papillary adenocarcinoma without lymph node metastasis and follicular carcinoma was 208% and 10% respectively. The expression rate of P53 gene was very low in adenoma with papillary hyperplasia and goiter, also its staining was faint.There exists marked statistical significance between undifferentiated thyroid carcinomas and differentiated ones; adenocarcinoma with lymph node metastasis and those without metastasis(P<001).The conclusion indicates that overexpression of P53 gene may be regarded as a guide of the extent of differentiation, metastasis and prognosis of thyroid carcinoma.

关 键 词：甲状腺癌 免疫组织化学 P_53癌基因 

分 类 号：R736.103[医药卫生—肿瘤] R361[医药卫生—临床医学]