ADC、FA值预测胶质母细胞瘤术后放射治疗疗效  

ADC and FA changes of glioblastomas after surgery: possible prediction of radiotherapy response

作　　者：曲金荣[1] 戴建平[1] 江涛[2] 李少武[1] 王奇峰[3] 蒋田仔[3] 艾林[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经影像中心,北京100050 [2]首都医科大学附属北京天坛医院神经外科胶质瘤中心,北京100050 [3]中国科学研究院自动化研究所,北京100190

出　　处：《中国医学影像技术》2008年第10期1534-1538,共5页Chinese Journal of Medical Imaging Technology

基　　金：北京市科技新星B类(20078052);十一五国家科技支撑计划重点项目(2007BAI05B08)

摘　　要：目的对照观察胶质母细胞瘤术后放射治疗前、放射治疗中弥散加权成像的变化与放射治疗的疗效,评价表观弥散系数(ADC)、部分各向异性(FA)在预测其疗效中的作用。方法回顾性分析19例术后证实的胶质母细胞瘤患者弥散成像的变化与放射治疗疗效。测量放射治疗前一周内、放射治疗中(放射剂量达30 Gy)残存肿瘤及瘤周组织的ADC值、FA值,根据放射治疗结束后4周与放射治疗前的MR图像显示肿瘤大小的变化将放射治疗疗效分为CR、PR、SD和PD 4组,对照观察其ADC、FA值与放射治疗疗效。结果CR组残存肿瘤的ADC值放射治疗中明显高于治疗前,而PD组残存肿瘤的ADC值放射治疗前后无明显变化。PD组瘤周组织的ADC值放射治疗中明显增高、FA值明显降低。结论通过胶质母细胞瘤术后残存肿瘤及瘤周组织的ADC、FA值能预测其放射治疗的疗效。Objective To investigate value of diffusion-weighted imaging （DWI） and apparent diffusion coefficient （ADC）, fractional anisotropy （FA） in the prediction of radiotherapy （RT） responses for glioblastomas after surgical operations. Methods Nineteen glioblastoma after surgery were examined by DWI before RT and at 30 Gy middle RT. ADC and FA values on DWIs both in the residual tumoral tissue and peritumoral tissue were measured before RT and at 30 Gy middle RT, and RT responses were classified as group of CR, PR, SD and PD By comparison of pretreatment and postchemoradiotherapy scans. The correlation between the ADC and FA and treatment response of 4 weeks after the complement of RT was evaluated as well. Results The ADC of the residual tumors was greater at 30 Gy middle RT than that before RT in CR groupl and no obviously change at 30 Gy middle RT than before RT in PD group. The ADC of peritumoral tissue revealed dramatic increased at 30 Gy middle RT, and the FA of peritumoral tissue showed significant decreased at 30 Gy middle RT after RT in PD. Conclusion Changes in ADC and FA of tumoral and peritumoral tissue may be helpful to predict the response of glioblastomas after surgery to RT.

关 键 词：磁共振成像 胶质母细胞瘤 放射治疗 

分 类 号：R730.264[医药卫生—肿瘤] R445.2[医药卫生—临床医学]