超声造影微血管显像测量乳腺病变大小的初步研究  

Usefulness of microvascular imaging in breast lesions assessment

作　　者：刘赫[1] 姜玉新[1] 刘吉斌 朱庆莉[1] 孙强[3] 常晓燕[4] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院超声诊断科,北京100730 [2]美国ThomasJefferson大学放射系,费城19107 [3]中国医学科学院北京协和医学院北京协和医院乳腺外科,北京100730 [4]中国医学科学院北京协和医学院北京协和医院病理科,北京100730

出　　处：《中国医学影像技术》2008年第10期1600-1603,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(30570529)

摘　　要：目的研究超声造影微血管显像在乳腺病变大小测量中的价值。方法对在北京协和医院进行乳腺手术的104例患者共104个病灶进行超声造影微血管显像,将超声造影微血管显像测得的病灶大小与常规超声及病理测得的病灶大小进行比较,分析超声造影微血管显像与常规超声测值差异的病理组织学基础。结果62.7%(27/43)乳腺癌超声造影微血管显像较常规超声测值增大,仅1例乳腺良性病变(肉芽肿性乳腺炎)超声造影微血管显像较常规超声测值增大,两组间差异有显著性(P=6.16×10^(-12))。乳腺癌超声造影微血管显像病变测值增大区病理主要为导管内癌或浸润癌伴导管内癌成分。1例肉芽肿性乳腺炎超声造影微血管显像病变测值增大区病理为炎症。结论超声造影微血管显像病变大小测值较常规超声增大多见于乳腺癌,测值增大区病理以恶性为主。Objective To evaluate the usefulness of micro vascular imaging （MVI） in the diagnosis of breast lesions, and compare it with conventional ultrasound. Methods In 104 patients with 104 breast tumors scheduled for surgical tumor removal, MVI was performed after administration of SonoVue. All breast lesions, US images, which include conventional US and MVI, were reviewed and correlated with histopathologic features. Results Among the 104 lesions, 62.7% （27/43） malignant lesions increased in size at MVI compared with conventional US, and pathology showed that the area corresponding to increased size was mainly ductal carcinomas in situ （DCIS） or invasive carcinoma with DCIS component. Only 1 granulomatous mastitis in 60 benign lesions increased in size at MVI due to inflammatory cell infiltration at the periphery. There was a significant difference between the malignant and benign groups （P〈0. 05）. Conclusion Breast malignant lesions are more likely to increase in size at MVI compared with conventional US, which is mainly due to DCIS or invasive cancer with DCIS component in the corresponding area.

关 键 词：乳腺肿瘤 造影剂 微血管显像 病理 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]