壮阳胶囊对利培酮治疗的精神分裂症患者血清催乳素的影响  

Effects of Zhuangyang Capsules on the Serum Prolactin of Schizophrenic Patients Treated with Risperidone

作　　者：陈振华[1] 王高华[1] 王晓萍[1] 李莉[1] 肖迪[1] 

机构地区：[1]武汉大学人民医院精神科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2008年第6期798-800,共3页Medical Journal of Wuhan University

基　　金：美国Stanley基金资助项目(编号:TS200301)

摘　　要：目的:探讨壮阳胶囊对利培酮治疗的精神分裂症患者血清催乳素的影响。方法:将76例符合DSM-Ⅳ标准的精神分裂症患者随机分为利培酮联合壮阳胶囊(试验组,n=39)和利培酮联合安慰剂(对照组,n=37),治疗8周。于基线及治疗第8周末测定血清催乳素浓度。用阳性与阴性症状量表(PANSS)评定精神症状。结果:壮阳胶囊治疗8周后血清催乳素浓度降低,与治疗前比较具有统计学意义(P<0.01);安慰剂治疗8周后血清催乳素浓度增加,与治疗前比较具有统计学意义(P<0.01);壮阳胶囊治疗后血清催乳素浓度平均降低26.51μg/L,安慰剂组平均增加15.56μg/L,两组比较具有统计学意义(P<0.01)。壮阳胶囊对男性、女性精神分裂症患者血清催乳素的影响无统计学意义(P>0.05)。结论:壮阳胶囊能有效降低由利培酮引起的血清高催乳素水平。Objective： To investigate the effect of Zhuangyang capsule, a traditional Chinese medicine, on the serum prolactin of schizophrenic patients treated with risperidone. Methods： All 76 schizophrenic patients who met the DSM-N criteria for schizophrenia were randomized for 8 weeks treatment with either Zhuangyang capsule （trial group, n=39） or placebo capsule （control group,n=37） added on risperidone. The serum level of prolaetin was measured at baseline and 8 weeks. Positive and negative syndrome scale （PANSS） was used to evaluate the psychotic symptoms. Results： For the trial group, the serum level of prolactin decreased significantly after 8 weeks treatment （P〈0.01）, while the serum level of prolactin increased significantly for the control group （P〈0.01）. There was a significant difference in improvement of the serum level of prolactin in trial group compared with that of control group （decreased 26.51 ng/ml vs increased 15.56 ng/ml） （P〈0.01）. The effect of Zhuangyang capsule on the serum prolactin of schizophrenic patients had no significant difference between male and female groups. Conclusion： Zhuangyang capsules can effectively decrease the higher serum level of prolactin induced by risperidone.

关 键 词：壮阳胶囊 精神分裂症 高催乳素血症 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]