大肠癌组织中促红细胞生成素受体表达与微血管密度的关系  

Relationships of erythropoietin receptor expression and microvascular density in colorectal carcinoma tissues

作　　者：方文成[1] 崔红侠[1] 孙卫红[1] 寇治民[2] 

机构地区：[1]山东省日照市人民医院普外科,山东日照276800 [2]兰州大学第二医院普外科,甘肃兰州730010

出　　处：《中国现代普通外科进展》2008年第5期402-404,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨大肠癌组织中促红细胞生成素受体(erythropoietin receptors,Epo-R)表达与肿瘤微血管密度(microvessel density,MVD)和临床病理特征的关系。方法:采用免疫组织化学SP法对60例大肠癌组织、20例正常大肠组织中Epo-R和MVD进行检测。结果:60例大肠癌组织均检测到Epo-R的表达。大肠癌组织MVD值为30.8±9.5,显著高于正常大肠组织的4.1±2.5(P<0.01)。MVD水平与大肠癌患者年龄、肿瘤浸润深度、淋巴结转移、远处转移、临床分期有显著相关性(P<0.05)。Epo-R表达与大肠癌组织MVD成正相关。结论:Epo-R在大肠癌组织中有异常高表达,且与MVD和临床病理特征成正相关,可能在肿瘤新生血管形成中有重要作用。Objective：To investigate the correlation between erythropoietin receptor（Epo-R）expression and microvascular density（MVD）in colorectal carcinoma tissues.Methods：Expression of erythropoietin receptor and microvascular density in 60 specimens of colorectal carcinoma and 20 normal colorectal specimens were investigated by immunohistochemistry.Results：Epo-R expression was found in all the colorectal carcinoma tissues.The level of MVD was much higher in colorectal carcinoma than that in the corresponding normal tissues（30.8±9.5 vs 4.1±2.5（P〈0.01）.Moreover,the level of MVD was significantly correlated with the patient age,depth of tumor invasion,lymph node metastasis,distant metastasis,clinical stage（P〈0.01）.The expression of Epo-R was positively correlated with MVD（P〈0.01）.Conclusion：Epo-R expression is upregulated,which is positively correlated with MVD and clinical pathological characteristics.

关 键 词：大肠肿瘤 促红细胞生成素受体 微血管密度 

分 类 号：R735.3[医药卫生—肿瘤]