氯喹、硝喹、乙胺嘧啶对巨噬细胞释出TNF的影响  

Effect of chloroqine、nitroquine、pyrimethamine on the release of TNF from macrophages

作　　者：孟德胜[1] 邓淑凤[1] 吕金胜[1] 陈晓红[1] 胡友梅[1] 

机构地区：[1]第三军医大学药理学教研室,重庆630038

出　　处：《中国药理学通报》1997年第5期458-460,共3页Chinese Pharmacological Bulletin

摘　　要：目的观测3种抗疟药对疟原虫诱导的大鼠腹腔巨噬细胞释放肿瘤坏死因子（TNF）的影响。方法：以酶联免疫法检测细胞培养液中TNF的含量。结果：感染约氏疟原虫的红细胞可诱导大鼠腹腔巨噬细胞释放TNF，12h时释出量达高锋。氯喹、硝喹明显抑制TNF的释放，乙胺嘧啶作用不明显。结论：氯喹、硝喹抑制TNF释放可能是其抗疟作用机制之一。To examine the effect ofthree anti-malaria drugs on the release of tumornecrosis factor (TNF ) from rats peritonealmacrophages. METHOD Enzyme-linked mmunosorbant assay. RESULTS Erythrocyte in-fected by Plasmodium yoelii can induce TNF releasefrom macrophages;At 12th hour,the levelof TNF reaches its peak.Chloroqune and nitroquine have obious inhibitive effect on the releasing of TNF,but pyrimethamine shows no effect.CONCLUSIONS:The results suggest tha the inhibition of TNF may be a part of antimalaria effectof chloroquine and nitroquine.

关 键 词：抗疟药 氯喹 乙胺嘧啶 肿瘤坏死因子 巨噬细胞 

分 类 号：R978.61[医药卫生—药品] R531.305[医药卫生—药学]