梗阻性黄疸应激时大鼠胃粘膜血流减少的原因探讨  

The decrease of gastric mucosal blood flow in obstructive jaundice under stress

作　　者：杨乃众[1] 徐为[1] 段建中[1] 李占文[1] 李晓强[1] 牟东成[1] 杜如昱[1] 

机构地区：[1]北京医科大学人民医院普外科

出　　处：《中华医学杂志》1997年第9期692-694,共3页National Medical Journal of China

摘　　要：研究梗阻性黄疸应激时胃粘膜血流减少的原因。方法用结扎总胆管的大鼠冷束缚应激模型，测定胃粘膜血流和胃粘膜中内皮素１（ＥＴ－１），血管紧张素Ⅱ（Ａｎｇ－Ⅱ）和胃粘膜组胺Ｈ２受体（Ｈ２受体），肾上腺素能α１受体（α１受体）的变化，以及应激前使用抗ＥＴ－１血清、依那普利、甲氰米胍、酚妥拉明后胃粘膜血流的改变。结果梗阻性黄疸应激时胃粘膜ＥＴ－１和Ａｎｇ－Ⅱ明显增加，Ｈ２受体和α１受体明显减少和胃粘膜血流明显减少。应激前使用它们的拮抗物胃粘膜血流明显增加。结论应激时胃粘膜中ＥＴ－１和Ａｎｇ－Ⅱ增加及Ｈ２受体和α１受体减少可引起胃粘膜血流减少。应激前使用它们的拮抗物可改善胃粘膜血流，它们有保护胃粘膜的作用。bjective To investigate the cause of decrease of gastric mucosal blood flow (GMBF) in obstructive jaundice under stress. Methods With common bile duct ligation (CBDL) in Wistar rats under cold restraint stress, GMBF and the content of Endothelin 1, Angiotensin Ⅱ, H 2, α 1 receptor in gastric mucosa were measured. Before stress anti ET 1 serum, Enalapril, Cimentidine and Phetolamini were administrated, and the change of GMBF was studied. Results GMBF was significantly decreased in CBDL in stress than those in control subjects. The content of ET 1 and Ang Ⅱ was significantly inceaced, the density of H 2 and α 1 receptor was significantly decreased. Before stress antagonist was administrated, and GMBF was significantly increaced. Conclusion GMBF was decreased by increased ET 1, Ang Ⅱ and decreased H 2, α 1 receptor in CBDL under stress. Antagonist improved gastric mucosal blood flow. They had protection from gastric mucosa.

关 键 词：梗阻性黄疸 胃粘膜血流速度 应激性溃疡 

分 类 号：R575[医药卫生—消化系统] R573.101[医药卫生—内科学]