醒髓汤对大鼠脊髓损伤组织一氧化氮含量影响的实验研究  

The Effect of Xingsui Decoction on Nitric Oxide in Spinal Cord Injury Tissue

作　　者：谭龙旺[1] 杨利学[1] 杨毓华[1] 李小群[1] 王晓玲[1] 孙智平[1] 

机构地区：[1]陕西中医学院附属医院骨科,陕西咸阳712000

出　　处：《中国中医骨伤科杂志》2008年第11期29-31,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

摘　　要：目的:观察醒髓汤(XST)对大鼠脊髓损伤后组织一氧化氮含量变化的影响,探讨XST在脊髓继发性损伤中的作用。方法:SD大鼠60只随机分组,改良的ALLEN’S法制成脊髓损伤模型,XST治疗7天,另设强的松龙对照组、模型组及空白组,观察伤后1h、8h、24h、3天、7天脊髓NO含量变化。结果:脊髓损伤后NO含量立即显著升高,至8h达到高峰,而后逐渐下降,醒髓汤组NO含量明显降低,与其它组相比差异有统计学意义(P<0.01)。结论:脊髓损伤后NO的升高是导致脊髓继发性损伤的重要因素,而醒髓汤能明显抑制脊髓损伤后组织NO含量的升高,改善脊髓损伤后的神经功能。Objective：To investigate the effect of Xingsui Decoction （XD） on the change of nitric oxide （NO） content in experimental spinal cord injury （SCI） rats. Methods： The models were established by improved Allent＇s methods. All rats were divided into SD group, prednisolone group, model group and control group. The NO content in injured spinal was ob- served at 1st hour, 8th hour, 3rd day and 7th day. Results：A significant increase of NO was found immediately after SCI. The NO content was highest at 8th hour, and then dropped clown slowly. The NO content in XD group was significantly decreased compared with other groups （P〈0.01）. Conclusion： NO increase might play an important role in secondary le sion of SCI. XD can obviously restrain the increase of NO after SCI and improve the neurological function.

关 键 词：脊髓损伤/中医疗法 一氧化氮 醒髓汤 

分 类 号：R-33[医药卫生] R243