蛋白酶D在恶性纤维组织细胞瘤中的表达及意义  

Expression of cathepsin D in malignant fibrous histiocytoma and its significance

作　　者：刘贵秋[1] 王玉学[1] 郝克强[1] 郝玢[1] 李正民[1] 高峥嵘[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院骨科,150081

出　　处：《中国肿瘤临床与康复》2008年第5期408-410,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：黑龙江卫生厅资助项目(2004-152)

摘　　要：目的研究组织蛋白酶D(Cathepsin D,Cath-D)在恶性纤维组织细胞瘤(malignant fi-brous histiocytoma,MFH)组织中的蛋白表达情况,探讨其在MFH发生发展中的作用,为阐明MFH的发病机制提供科学依据。方法应用免疫组化方法检测65例MFH组织的Cath-D的蛋白表达情况,分析Cath-D蛋白表达率与临床病理特征之间的关系。结果Cath-D阳性表达主要定位于细胞浆。65例MFH组织中Cath-D蛋白阳性表达率为75.4%,I^II期Cath-D阳性率为60.0%,III~Ⅳ期Cath-D阳性率为88.6%,两者相比差异有显著性(P<0.01)。Cath-D的阳性表达率与病理分化程度和生存期显著相关(P<0.01)。结论Cath-D在MFH发生发展中起重要作用,是判断MFH侵袭、转移和预后的重要指标。Objectives To investigate the expression of cathepsin D in malignant fibrous histiocytoma（MFH） tissues,and to explore the role of cathepsin D in development and progress of MFH,and to provide scientific evidence in order to elucidate the pathogenesis of MFH. Methods The expression of cathepsin D in 65 MFH tissues was examined by immunohistochemical method,and the relation between the protein expression rate and clinical and pathological characteristics was analyzed. Results The positive expression of cathepsin D was located mainly in the cytoplasm. The positive expression rate of cathepsin D were 75.4% in 65 MFH tissues,60. 0% in stage Ⅰ-Ⅱ, and 88.6% in stage Ⅲ-Ⅳ. There were statistically significant differences（ P 〈0.01 ）. The positive expression rate of cathepsin D was significantly correlated with degree of pathological differentiation and life span （ P 〈0. 01 ）. Conclusions The results demonstrate that cathepsin D may play an important role in the development and progression of MFH. Cathepsin D can be used as an important marker of invasion, metastasis and prognosis.

关 键 词：组织蛋白酶D 免疫组化 恶性纤维组织细胞瘤 

分 类 号：R730.2[医药卫生—肿瘤]