1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-5-甲氧羰基-3-吡啶羧酸的合成  

Synthesis of 2,6-Dimethyl-4-(3-nitrophenyl)-5-methoxycarbonyl-1,4-dihydropyridine-3-carboxylic acid

作　　者：吴杰伟[1] 丁盈红[1] 李若琦[1] 

机构地区：[1]广东药学院药科学院

出　　处：《广东药学院学报》2008年第5期493-495,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的改进1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-5-甲氧羰基-3-吡啶羧酸的合成方法。方法非均相反应中引入相转移催化剂,分析时间、溶剂、催化剂对反应的影响。结果以四正丁基氯化铵作相转移催化剂,甲醇作溶剂、饱和NaOH水溶液中反应4h,得到目标产物,产率为81%。结论改进的反应条件可以较大缩短反应时间,达到选择性水解的目的。The synthetic procedure of 2,6-dimethyl-4-（3-nitrophenyl）-5-methoxycarbonyl-1,4-dihydropyridine-3-earboxylie acid was modified under phase transfer catalysis. The effects of catalyst amount, reaction time and solvent on the yield were investigated. The target compound was obtained in a total yield of 81% when using methanol as solvent under 70 ℃ for 4 h.

关 键 词：1 4-二氢-2 6-二甲基-4-(3-硝基苯基)-5-甲氧羰基-3-吡啶羧酸 相转移催化剂 选择性水解 

分 类 号：R914[医药卫生—药物化学]