根除幽门螺杆菌与胃食管反流病的关系研究  

Study on the relationship between gastro-esophageal reflux disease and H.pylori eradication

作　　者：王木生[1] 李玉芳 项文坤[3] 熊锋宝[3] 

机构地区：[1]江西护理职业技术学院医学技术二系临床教研室,江西南昌330029 [2]江西妇幼保健院急诊科 [3]南昌大学第三附属医院消化内科

出　　处：《胃肠病学和肝病学杂志》2008年第11期887-889,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：江西省卫生厅科技计划课题(20072013)

摘　　要：目的探讨根除幽门螺杆菌(H.pylori)与胃食管反流病(GERD)的关系。方法本研究采用食管内24 h pH监测的方法,定量观察H.pylori阳性GERD患者根除H.pylori和单用兰索拉唑治疗3月后食管酸暴露的变化,以及H.pylori阳性慢性浅表性胃炎(CSG)根除H.pylori和姑息治疗3月后食管酸暴露的变化。RE组:反流性食管炎(RE)表现患者60例,按就诊门诊号随机分为治疗组和对照组。治疗组采用丽珠唯三联+兰索拉唑方案,对照组单用兰索拉唑。CSG组:慢性浅表性胃炎(CSG)患者60例,按就诊门诊号随机分为治疗组和对照组。治疗组均采用丽珠唯三联方案,对照组不采用药物治疗。以上两组待H.pylori根除后,对比研究H.pylori根除组和对照组3月后食管24 h pH监测参数。结果RE组:H.pylori根除和单用兰索拉唑治疗3月后两组24 h食管pH监测主要观察5项指标均无显著性差异(P>0.05)。CSG组:H.pylori根除和姑息治疗3月两组24 h食管pH监测主要观察5项指标均无显著性差异(P>0.05)。结论GERD患者根除幽门螺杆菌后食管酸暴露无明显改变,CSG患者根除幽门螺杆菌后食管酸暴露无明显改变,H.pylori感染可能与GERD的转归和发生无关。Objective To investigate the relationship between gastro-esophageal reflux disease（GERD） and H. pylori eradication. Methods We evaluated the changes of intraluminal esophageal acidity in 3 months after the treatment which one was by H. pylori eradication and the other was by simple lansoprazole on GERD patients, and the changes of H. pylori eradication and non-therapy with CSG patients by 24-hour esophageal pH-monitoring. Consecutive symptomatic reflux esophagitis（RE） patients were studied, 60 patients were divided randomly into 2 groups ： one groups as H. pylori eradication ＋ lansoprazole therapy and the other as simple lansoprazole therapy. Consecutive symptomatic chronic superficial gastritis （CSG） patients were studied, 60 patients were divided randomly into 2 groups： one group as H. pylori eradication therapy and the other as non-therapy. 24-hour esophageal pH-monitoring was underwent at 3 months after the therapy. Results No significant difference was observed in terms of 24-hour esophageal pH-monitoring between the group with H. pylori eradication ＋ lansoprazole therapy and the group with simple lansoprazole therapy in GERD patients. No significant difference was observed in terms of 24-hour esophageal pH-monitoring between the group underwent H. pylori eradication therapy and the group underwent non-therapy. Conclusion Eradication of H. pylori does not effect the prevalence of RE with GERD and CSG patients. H. pylori has not a protective effect against GERD nor accelerates the development of GERD.

关 键 词：幽门螺杆菌 胃食管反流病 食管24 H PH监测 

分 类 号：R57[医药卫生—消化系统]