乳腺浸润性导管癌中survivin的表达及意义  

Expression and Significance of Survivin in Breast Invasive Carcinoma

作　　者：谢晖[1] 周茜[1] 钱宁[1] 陆澄[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院乳腺科,210004

出　　处：《中国误诊学杂志》2008年第36期8826-8828,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:检测乳腺癌中survivin的表达并探讨其临床意义。方法:用免疫组化SP法检测乳腺癌组织中sur-vivin、ER、PR、p53及Her2蛋白的表达。结果:乳腺癌组织中survivin蛋白的阳性表达率明显高于癌旁乳腺组织分别为72.1%、9.8%,但其表达与survivin、ER、PR、P53、Her2和淋巴结转移状况无明显相关。结论:乳腺癌组织中survivin表达与乳腺癌的发生相关,但作为预后指标需要进一步评价。Objective：This paper is to examine the expression of survivin and its significance in breast invasive carcinoma. Methods ：Expression of survivin in breast carcinoma tissue and para-tumor breast tissue was examined. Its relationships with ER, PR, Her2, p53 and axillary lymph node status were analysed. Results：Expressions of survivin in breast carcinoma tissue and para tumor breast tissue were 72.1%, 9.8% respectively. There was statistical significance between those two kinds of tissues. The correlation between survivin and other clinical and pathological characters was not seen. Conclusions ：Survivin plays its role in breast tumorigenesis ,its relationship with other clinical and pathological characters needs further study.

关 键 词：乳腺肿瘤/代谢/病理学 癌 导管 乳腺/病理学 淋巴转移 微管相关蛋白质类/代谢 人类 

分 类 号：R737.9[医药卫生—肿瘤]