正交实验优选阿魏胶囊的提取工艺  

Optimization of the extraction process for AWei capsule by orthogonal experiment

作　　者：薛洁[1] 张海英[1] 

机构地区：[1]新疆医科大学附属中医医院,乌鲁木齐830000

出　　处：《中华中医药杂志》2008年第11期1030-1033,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家"十一五"科技支撑计划资助项目(No.2007BAI20B077)

摘　　要：目的:优选阿魏胶囊的提取工艺。方法:以没食子酸含量和浸膏得率为综合评价指标,采用正交试验设计优选出阿魏胶囊的水提取工艺。以厚朴酚、和厚朴酚含量和浸膏得率为综合评价指标,采用正交试验设计优选出阿魏胶囊的乙醇提取工艺。结果:优选出的水提工艺为:药材加10倍量水,回流提取2次,每次1.5h。优选出的醇提工艺为:80%乙醇回流提取2次,每次1.5h,每次加醇量为药材量的6倍。结论:优选得到的提取工艺稳定、合理、可行。Objective： To study the extraction process of AWei capsule. Methods： Taking the contents of gallic acid and the yield of extracts as assessment index to optimize water extraction process of AWei capsule with orthogonal experimental design. Taking the contents of magnolol,honokiol and the yield of extracts as assessment index to optimize ethanol extraction process of AWei capsule with orthogonal experimental design.Results： The optimal water extraction process of AWei capsule was extracting twice, every time lasted 1.Sh, every time added 14 times water. The optimal ethanol extraction process of AWei capsule was using 80% ethanol as solvent, extracting twice, every time lasted 1.5h, every time added 6 times solvent. Conclusion： The optimized extraction process is stable and reasonable.

关 键 词：阿魏胶囊 没食子酸 厚朴酚 和厚朴酚 正交试验 

分 类 号：TQ461[化学工程—制药化工]