首发与复发性抑郁症患者执行功能的比较  

The Comparison of Executive Function between First-episode and Recurrent Depressive Patients.

作　　者：徐晔[1] 陈晋东[2] 

机构地区：[1]中国.哈尔滨医科大学第一临床医学院,150001 [2]中南大学湘雅二医院

出　　处：《中国健康心理学杂志》2008年第11期1271-1273,共3页China Journal of Health Psychology

摘　　要：目的比较首发与复发性抑郁症患者的认知执行功能。方法对43例首发抑郁症患者以及48例复发抑郁症患者,采用17项汉密尔顿抑郁量表测定抑郁严重程度,采用威斯康星卡片分类测验测定执行功能,并进行治疗前后的执行功能比较。结果治疗前首发组与复发组各项执行功能指标均较对照组差(P<0.05);分类数首发组高于复发组(P<0.05)。治疗后首发组除分类数外,其它指标均与对照组有统计学差异(P<0.05);复发组各项指标仍较对照组为差(P<0.05);首发组与复发组治疗后比较,各项指标首发组均优于复发组(P<0.05);治疗后,无论是首发组还是复发组,其HAMD17评分及执行功能的各项指标均有显著性改善(P<0.05)。结论首发与复发性抑郁症患者均存在执行功能的损害;复发性抑郁症患者的执行功能损害更为严重。药物治疗后,首发、复发性抑郁症患者执行功能均有一定程度的恢复。Objective To evaluate the executive function of first-episode and recurrent depression. Methods 43 first-episode depression patients, 48 recurrent depression patients were enrolled. The severity of depression were evaluated by Hamilton Depression Scale- 17 （HAMD--17）. Wisconsin Card Sorting Test was used to measure the executive function. The executive function were contrasted to pretherapy. Results The executive function of first-episode group and recurrent group were no good comparing to control before treatment （P〈0.05）. First-episode group was higher in categories completes than recurrent group（P〈0.05）. Except categories completes, there were significant statistics difference between first-episode group and control group in other items of WCST after treatment （P〈0. 05）. The lower scores of each item of WCST in recurrent group contrast to control after treat- ment （P〈0. 05）. After treatment, the scores of first-episode group were better than recurrent group （P〈0. 05）. The significant improvement were seen in scores of HAMD--17 and each item of WCST in two depressive groups （P〈0.05）. Conclusion There are impairment of executive function in both first-episode and recurrent group. To compare with first-episode group, the more severity of impairment of executive function in recurrent group. The executive function of the two depressive groups are repaired partly after drug treatment.

关 键 词：抑郁症 执行功能 首发 复发 

分 类 号：R749.94[医药卫生—神经病学与精神病学] R781.505[医药卫生—临床医学]