负压空化强化提取长春花中生物碱的工艺参数优化  

Optimization of process parameters of extracting alkaloids from Catharanthus roseus by vacuum cavitation extraction technique

作　　者：杨磊[1] 张琳[1] 田浩[1] 牛卉颖[1] 祖元刚[1] 

机构地区：[1]东北林业大学森林植物生态学教育部重点实验室,黑龙江哈尔滨150040

出　　处：《化工进展》2008年第11期1841-1845,共5页Chemical Industry and Engineering Progress

基　　金：国家科技支撑计划项目(2006BAD18B04);国家林业局重点科学技术研究项目(2006-58);东北林业大学青年科研基金项目(07041)

摘　　要：采用负压空化法对长春花中的生物碱进行提取研究,以长春花中3种主要生物碱长春碱、文多灵和长春质碱的提取率评价提取效果,考察了提取溶剂、pH值、酸性调节物、提取时间、料液比和提取次数等因素对提取效果的影响。结果表明:以pH值为1.5的硫酸50%甲醇溶液作为提取溶剂,料液比1∶10,空化提取25min,空化提取3次时,提取效果最好;与其它提取方法相比,负压空化法更适合用于含量低但价格昂贵的长春碱的提取,提取率达到0.082‰。Vacuum cavitation extraction technique was used to extract the alkaloids from Catharanthus roseus and the extraction yields of the main three alkaloids vinblastine, vindoline and catharanthine were used to estimate the extraction results. The effects of different solvents, pH value, acid, extraction time, solid-liquid ratio and extraction time on extraction yields were studied. The optimum parameters of extraction process by vacuum cavitation were as follows： extraction solvent was 50% methanol in sulfuric acid solution; pH value of extraction solvent was 1.5; solid-liquid ratio was 1 ： 10： C. roseus was extracted 3 times with each 25min by vacuum cavitation. The results showed that vacuum cavitation extraction technique was better than other extraction methods for low-concentration and high-value vinblastine with extraction yield up to 0.082‰.

关 键 词：长春花 生物碱 负压空化提取 

分 类 号：TQ464.4[化学工程—制药化工]