医药中间体17α-羟基-21-碘黄体酮的合成工艺改进  

Improvement of Synthesis Techics of Medical Intermediat 17α-Hydroxy-21-iodopregn Progesterone

作　　者：谢何青[1] 李敬芬[1] 

机构地区：[1]湖州师范学院生命科学学院,浙江湖州313000

出　　处：《化工文摘》2008年第5期34-35,共2页

摘　　要：以羟基黄体酮和一氯化碘为原料,合成17α-羟基-21-碘黄体酮。考察溶剂体系、反应温度及原料配比对反应结果的影响。得到最佳反应条件为:反应溶剂为水、反应温度为0～5℃、羟基黄体酮与一氯化碘摩尔比为1.0:1.0,粗品精制后收率可达98%。17 α -hydroxy -21 - iodine progesterone was synthesized using hydroxy-progesterone and an iodine chloride. The influence of the system solvent, the temperature and the ratio of raw materials on the outcome of the reaction was investigated. The best conditions was obtained： the reaction solvent was the water, the reaction temperature was 0-5 ℃, hydroxy-progesterone and iodine chloride was 1.0：1.0, the yield of crude more than 98 percent after refining.

关 键 词：17α-羟基-21-碘黄体酮 一氯化碘 碘化反应 合成 

分 类 号：TQ560.6[化学工程—炸药化工] TS227[轻工技术与工程—粮食、油脂及植物蛋白工程]