膜联蛋白-1与肿瘤  

Annexin I and Tumor

作　　者：朱逢佳[1,2,3] 曾苏[3] 曹江[1,2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院临床医学研究所 [2]浙江省生物治疗重点实验室,杭州310016 [3]浙江大学药学院药物分析及药物代谢研究室,杭州310016

出　　处：《细胞生物学杂志》2008年第5期581-585,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30471955)~~

摘　　要：膜联蛋白-1(annexin I,ANXA1,lipocortin I)是膜联蛋白超家族中的一员,它参与细胞生长、增殖及凋亡等重要的生命过程,其表达在多种类型组织的癌前病变及肿瘤组织中与相应的正常组织中相比均有明显差异,与肿瘤细胞的恶性生长和多药耐药等表型密切相关。深入研究ANXA1的功能有助于完善人们对肿瘤发生发展机制的认识,并有助于肿瘤的诊断、治疗和预后。Annexin I （ANXA1, lipocortin I） is a member of the annexin superfamily, which is involved in important biological processes such as cell growth, proliferation and apoptosis. There is significant difference between the expression of ANXA1 in various types of precancerous and tumor tissues and that in their normal counterparts, and the expression level of ANXA1 is closely related to the malignant growth and multidrug resistance of tumor cell. More functional studies of ANXA1 will.improve our understanding of the mechanism of tumor development and progression, and is helpful to the diagnosis, treatment and prognosis of tumor.

关 键 词：膜联蛋白-1 肿瘤 凋亡 多药耐药 

分 类 号：R730.2[医药卫生—肿瘤]