大鼠牙髓炎组织中细胞间粘附分子-1的表达及意义  

Expressions of intercellular adhesion molecule-1 in experimental pulpitis of rat

作　　者：黄晓山[1] 才晓慧[1] 马勇全[1] 

机构地区：[1]南方医科大学附属珠江医院口腔科,广州510282

出　　处：《现代口腔医学杂志》2008年第6期603-605,共3页Journal of Modern Stomatology

摘　　要：目的观察细胞间粘附分子-1(ICAM-1)在鼠实验性牙髓炎中的变化,探讨其在实验性牙髓炎中的作用。方法建立大鼠实验性牙髓炎模型,用免疫组化法及图像分析技术检测正常牙髓、牙髓炎即刻组、1天组、3天组、5天组、7天组中ICAM-1的表达情况。结果正常牙髓组织中存在ICAM-1,ICAM-1在实验组比正常组阳性表达增强,光密度值增高,实验组第一天达到高峰,到第七天逐渐减少,总体差异有统计学意义。结论与正常牙髓组织相比,炎症牙髓组织中ICAM-1表达增强,提示ICAM-1在牙髓炎发展过程中起一定作用。Objective To observe the expression of intercellular adhesion molecule - 1 （ICAM - 1 ） in experimental pulpitis of rat. Methods Rat experimental pulpitis was established. ICAM - 1 expression was detected by immunohistochemical staining in normal dental pulp, at and in puppitis at day 0, 1, 3, 5, and 7 respectively. The staining was analyzed by imaging system. Results Image analysis showed that normal dental pulp tissue contained a small quantity of ICAM - 1. However, expression of ICAM - 1 was observed stronger in experiment pulpitis with the peak in the pulpits at day 1 and then gradually reduced. Conclusion This study showed that ICAM - 1 had a significant increase in the experiment pulpitis, suggesting that ICAM - 1 may play a role dental pulpitis.

关 键 词：ICAM-1 牙髓炎 大鼠 免疫组化 

分 类 号：R781.3[医药卫生—口腔医学]