C-met在乳腺癌组织中的表达及临床意义  

Expression of Proto-oncogen C-met in Breast Carcinoma Tissue

作　　者：王承正[1] 吴军召[1] 毛书明[1] 崔树德[1] 

机构地区：[1]河南省肿瘤医院乳腺科,郑州市450008

出　　处：《医药论坛杂志》2008年第21期25-27,共3页Journal of Medical Forum

摘　　要：目的了解原癌基因C-met在人乳腺癌组织中表达的规律,以及这种规律与肿瘤生物学行为的关系。方法应用SP免疫组织化学方法,检测60例乳腺浸润性导管癌,20例乳腺纤维腺瘤组织中原癌基因C-met的表达情况。结果原癌基因C-met在60例乳腺浸润性导管癌表达阳性率为65.00%,其与肿瘤组织学分级、临床分期、淋巴结转移相关(P<0.05),而与年龄、月经情况、肿瘤大小无关(P>0.05)。C-met在乳腺癌组织中的表达显著高于乳腺纤维腺瘤组织(P<0.010)。结论原癌基因C-met过度表达与乳腺癌的转移密切相关,对乳腺癌的发生发展起重要作用,对指导临床预防治疗有一定意义。Objective To explore the regularity of expression of proto - oncogn C - met in the human breast carcinoma and relationship between this regularity and biological behavior of tumor. Methods The expression of proto - oncogene C - met were measured by immunohistoehemical assay in 60 cases of infiltrative type of breast duet carcinoma tissue and 20 cases of breast fibroadenoma. Resuits The positive expression rates of proto - oncogen C - met in 60 cases of breast carcinoma was 65.00%, C - met expression was significantly correlated with histologic grade, stage of the tumor, lymph node metastasis （ P 〈 0.05 ）, but it was insignificantly correlated with ages,menstruation,tumor size（ P 〉0. 05）. The expression of C -met was significantly higher in the breast carcinoma than that in the breast fibroadenoma （ P 〈 0. 010）. Conclusion The overexpression of proto - oncogene C - met was closed correlated with the metastasis of the breast carcinoma, proto - oncogen C - met was possible the important part of CPHC circle, and the overexpression of C - met play a certain role in the development and guidance on clinical treatment of breast carcinoma.

关 键 词：乳腺癌 原癌基因 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]