内放疗支架治疗中晚期食管癌的临床应用研究  

Clinical study of innner radiative stent on esophageal carcinoma in middle and advanced stage

作　　者：刘爱民[1] 吴涛[1] 潘永林[1] 张盛[1] 王萍[1] 晏中锦[1] 卢丹萍[1] 雷德安[1] 

机构地区：[1]重庆市涪陵中心医院消化科,408000

出　　处：《中国实用医药》2008年第29期6-7,共2页China Practical Medicine

基　　金：重庆市涪陵区科委自然科学基金资助课题(项目编号:20061129)

摘　　要：目的探讨125I粒子支架治疗中晚期食管癌的疗效。方法122例患者分为治疗组(A组)62例,对照组(B组)60例,A组将剂量为0.6mCi的125I粒子(根据病变长度决定粒子数量)捆绑在带膜支架上放置,B组直接放置普通带膜支架,分别于3、6、12、18个月观察并发症发生情况、肿瘤生长转移情况、总生存率。结果A组在3、6、12个月肿瘤生长阻塞支架发生率显著低于B组,新增转移癌灶低于B组,平均生存时间明显长于B组(P<0.05)。结论125I粒子支架治疗食管癌可显著改善吞咽困难,有效阻止肿瘤生长、转移,提高生存质量,延长生存期。Objective To investigate the effect of stent with 125I seed in treatment of esophageal carci- noma in middle and advanced stage. Methods 122 patients were divided into therapeutic group,A group,62 cases and control group, B group, 60 cases. The cases in A group were treated by covered-metallic stent com- bined with 12~1 seed, the quantity of seeds decided by the length of lesion, the ones in group B were treated by covered-metallic stent. The complication, metastasis and total survive rate were explored after 3,6, 12, 18 months. Results The incidences of stent obstruction by carcinoma and new metastatic lesions were significantly lower than that of group B while the mean survival duration was significantly longer than that of group B after 3, 6,12 months individually. Conclusion Covered-metallic stent combined with 125U seed can improve the symp- tom of dysplasia and survival quality of patient, prevent the growth ancl metastasis of carcinoma, prolong the survival duration.

关 键 词：125I粒子 支架 食管癌 内窥镜检查术 

分 类 号：R735.1[医药卫生—肿瘤] R817.8[医药卫生—临床医学]