人类N-乙酰化酶2蛋白质三维结构的计算机模拟技术的研究进展  

The research progress of the computer simulation technology of three-dimension structure of human N-acetyltransferase2 protein

作　　者：朱志远[1] 袁靖[1] 李金恒[2] 

机构地区：[1]中国人民解放军第86医院药械科,安徽当涂243100 [2]南京军区南京总医院,江苏南京210002

出　　处：《中国药理学通报》2008年第11期1415-1418,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30472055)

摘　　要：NAT2是人体内重要的代谢酶,主要参与含氮药物的代谢。目前对NAT2基因序列测定和药物代谢等方面已经进行了大量的研究。近年来人们对蛋白质的三维(立体)结构的模拟越来越关注,但是对NAT2的三维立体结构以及它与药物结合的构效关系等研究仅处在一个起步阶段。该文对NAT2三维立体结构的构建的研究进展作一综述,着重介绍蛋白质立体结构的构建方法和工具的研究情况。N-acetyltransferase 2 is an important metabolic enzyme in the human body, participating mainly in the metabolism of medicine containing nitrogen. Presently a lot of researches have been undertaken in the respects like the determination of NAT2 genotype and drug metabolism and so on. In the recent years, more and more attention is paid to the simulation of threedimension （solid） structure of protein, but the study is just atthe outset on three - dimension structure of the NAT2 as well as its structure-function relationship when combined with drug. The research progress of construction of the three - dimension structure of NAT2 is summarized, emphasizing on its methods and tools.

关 键 词：NAT2 蛋白质三维结构 结构模拟 

分 类 号：R-05[医药卫生] R341.81