姜黄素固体分散体在小鼠体内的药代动力学  

Pharmacokinetics of curcumin solid dispersion in mice

作　　者：黄秀旺[1] 许建华[1] 吴国华[2] 温彩霞[1] 

机构地区：[1]福建医科大学药学院临床药理研究所 [2]福建医科大学药学院药学实验教学中心,福建福州350004

出　　处：《中国药理学通报》2008年第11期1525-1527,共3页Chinese Pharmacological Bulletin

基　　金：福建省重大专项前期研究项目资助项目(No2005YZ1010)

摘　　要：目的以姜黄素混悬液为对照,研究姜黄素-聚维酮固体分散体灌胃给药后在小鼠体内的药代动力学。方法按300mg·kg-1的剂量小鼠灌胃姜黄素固体分散体溶液或姜黄素混悬液,采用高效液相色谱法测定血浆中姜黄素含量,用DAS软件拟合房室模型,计算药动学参数。并测定了给药3h时药物的吸收率。结果姜黄素-聚维酮固体分散体在小鼠体内的药代动力学符合二室开放模型,主要药动学参数如下:T12α和T12β分别为16.4和266min,AUC为89.6mg·mL-1.min-1,Vd为763.9L,V1为51.0L,CL为1.99L·min-1。姜黄素-聚维酮固体分散体在胃肠道的吸收率是姜黄素混悬液的6.75倍。结论姜黄素固体分散体灌胃可显著增加姜黄素的生物利用度,血药浓度较高。Aim To study the pharmacokinetics of curcumin-pvp solid dispersion ig administration in mice in comparison with the free curcumin suspension. Methods Drugs were administered at a dose of 300 mg· kg^-1 via ig. The plasma concentration of curcumin was determined by HPLC, the pharmacokinetics were calculated by DAS verl. 0 program. Results The curcumin pharmacokinetics conforms to a two-compartment open model after a single ig dose of curcumin solid dispersion in mice. The parameters were as follows： T1/2α andT1/2β were 16.4 and 266. 1 min, respectively. AUC was 89. 6 mg · L^-1 · min^-1,Vd was 763.9 L,V1 was 51.0 L,and CL was 1.99 L · min^-1. The absorption rate of cureumin solid dispersion was 6.75 times as much as curcumin suspension. Conclusion The eurcumin solid dispersion improves the absorption of curcumin in vivo in mice evidently.

关 键 词：姜黄素 药代动力学 高效液相色谱 固体分散体 

分 类 号：R-332[医药卫生] R282.71