葡聚糖-多巴胺大分子前药的合成与表征  

Synthesis and characterization of dextran-dopamine macromolecule prodrug

作　　者：欧思曼[1] 张娟[1] 刘毅锋[1] 乔长安 高丽娟[1] 

机构地区：[1]西北大学应用化学研究所,陕西西安710069 [2]陕西出入境检验检疫局,陕西西安710068

出　　处：《西北大学学报（自然科学版）》2008年第5期763-766,共4页Journal of Northwest University（Natural Science Edition）

基　　金：陕西省教育厅专项基金资助项目(05JK306)

摘　　要：目的研究葡聚糖-多巴胺大分子前药的合成方法。方法采用琥珀酸酐作为连接基与葡聚糖(平均分子量20000,40000)反应,生成中间体葡聚糖丁二酸酯,再利用中间体的端羧基与多巴胺的氨基反应,合成出了两种葡聚糖-多巴胺大分子前药,并用红外、核磁对其进行了分析和表征。结果合成的两种大分子前药,产率都大于80%,多巴胺在两种前药中的含量(质量分数)均大于8%。结论该方法操作简单,反应条件温和,产率高,具有较好的应用前景。Aim To report a method for synthesis of dextran-dopamine prodrug.Methods Dopamine was covalently linked to dextran via succinic anhydride spacer.The average molecular weight used for dextran are 20 000 and 40 000,respectively,and the procedure of chemical modification for dextrans was conducted by a two-step：（1） preparation of dextran having carboxylic end groups;（2） synthesis of D20000-DA and D40000-DA.The two prodrugs were characterized by IR and 1H NMR analysis.Results The yields of two prodrugs were more than 80%,and the contents of dopamine in prodrugs were more than 8%.Conclusion The method of preparation of dextran-dopamine prodrug is simple and usable with mild condition.

关 键 词：葡聚糖 多巴胺 人工合成 

分 类 号：O621.3[理学—有机化学]