N,N′-二(2-吡啶甲酰胺基)-1,2-乙烷的合成  

Synthesis of N,N′-Bis(2-pyridinecarboxamide)-1,2-ethane

作　　者：赵颖俊[1,2] 冯晓亮[1] 史鸿鑫[2] 吾国强[1] 

机构地区：[1]浙江工业大学浙西分校化学与制药工程系,浙江衢州324000 [2]浙江工业大学绿色化学合成技术国家重点实验室培育基地,浙江杭州310014

出　　处：《化学世界》2008年第11期674-676,共3页Chemical World

基　　金：浙江省教育厅科研项目(20061237)

摘　　要：以2-吡啶甲酸与乙二胺为原料,采用亚磷酸三苯酯法合成N,N′-二(2-吡啶甲酰胺基)-1,2-乙烷。实验结果表明优化的反应条件为:反应温度90°C,反应时间3 h,n(亚磷酸三苯酯)∶n(2-吡啶甲酸)=0.7∶1,收率为85.6%。产品经HPLC分析,含量99.2%。化合物结构经MS、IR、1H NMR确证。亚磷酸三苯酯法具有操作简便、所得产品纯度高等特点。N, N＇-Bis（g-pyridinecarboxamide）-1, 2-ethane was synthesized for 2-pyridine-carboxylic acid and ethylenediamie with the method of triphenyl phosphite. The optimum conditions were obtained as follows： the molar ratio of triphenyl phosphite and 2-pyridinecarboxylic acid was 0.7：1, temperature and time of reaction were 90℃ and 3 h. The product was characterized by IR, MS and 1H NMR. The purity of the product was 99.2% and the yield is 85.6%. The results showed that the method of triphenyl phosphite had many advantages, such as easy to operate and high-purity of the product.

关 键 词：2-吡啶甲酸 N N'-二(2-吡啶甲酰胺基)-1 2-乙烷 亚磷酸三苯酯 合成 

分 类 号：O647[理学—物理化学]