头电针治疗血管性痴呆的临床多中心随机对照研究  

Clinically multi-central randomized controlled study on scalp electroacupuncture for treatment of vascular dementia

作　　者：张虹[1] 赵凌[1] 何成奇[2] 胡卡明[3] 刘军[4] 

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075 [2]四川大学华西医院 [3]成都中医药大学附属医院 [4]成都市中西医结合医院

出　　处：《中国针灸》2008年第11期783-787,共5页Chinese Acupuncture & Moxibustion

基　　金：国家中医药管理局课题项目:02-03LP45

摘　　要：目的:为针灸治疗血管性痴呆提供可靠证据。方法:采用多中心随机对照试验(RCT)的方法,将270例血管性痴呆患者随机分配到针药组、电针组和药物组。针药组采用头电针配合口服尼莫地平,电针穴取四神聪、百会、神庭、风池;电针组单纯采用头电针治疗;药物组单纯口服尼莫地平,均治疗6周。治疗前后分别进行简易精神状态检查量表(MMSE)、日常生活活动能力(ADL-R)量表和P300的检测。结果:患者认知状况的改善,针药组总有效率为86.59%,电针组为82.05%,药物组为43.21%,针药组与电针组均优于药物组;患者日常生活活动状况的改善,3组总有效率分别为59.76%、65.38%、32.10%,针药组与电针组均优于药物组。MMSE量表评分、ADL-R量表评分和P300检测中均显示,治疗后针药组和电针组较药物组差异均有统计学意义(P<0.01)。结论:头电针与头电针配合口服尼莫地平均能改善血管性痴呆患者认知功能和日常生活活动能力,疗效优于单纯口服尼莫地平,且安全性高。Objective To provide reliable evidence for acupuncture treatment of vascular dementia （VD）. Methods Multi-central randomized controlled trial method was adopted and 270 cases enrolled were randomly assigned to an acupuncture medicine group, an electroacupuncture group and a medication group. The acupuncture-medicine group were treated by scalp electroacupuneture on Sishencong （EX-HN 1）, Baihui （GV 20）, Shenting （GV 24）, Fengehi （GB 20） and oral administration of Nimodipine; the electroacupuncture group were treated with scalp electroacu puncture; the medication group were treated with simple oral administration of Nimodipine. They were treated for 6 weeks. Mini-mental state scale （MMSE）, ability of daily life-rating scale （ADL-R） and P300 were detected before and after treatment. Results The total effective rate for cognition improvement was 86. 59% in the acupuncture- medicine group, 82.05 % in the electroacupuncture group and 43.21% in the medication group, the electroacupuncture group and the acupuncture-medicine group being better than the medication group; and their total effective rates for improvement of ability of daily life were 59.76%, 65.38% and 32.10%, respectively, the electroacupuncture group and the acupuncture-medicine group being better than the medication group. Scores for MMSE and ADL-R and P300 examination indicated that there were significant differences as the acupuncture medicine group and the elec troacupuncture group compared with the medication group （P〈0.01）. Conclusion Scalp electroacupuncture or scalp electroacupuncture combined with oral administration of Nimodipine has a better therapeutic effect in improvement of recognition function and the ability of life activity than simple oral administration of Nimodipine with a high er safety.

关 键 词：电针 头针 痴呆 血管性 随机对照试验 MMSE量表 ADL-R量表 

分 类 号：R749.13[医药卫生—神经病学与精神病学] R245.97[医药卫生—临床医学]