莫沙必利联合奥美拉唑治疗反流性食管炎的临床观察  

The Effect of Mosapride Combined with Omeprazole on Reflux Esophagitis

作　　者：曹欣[1] 曹大春[1] 张哲永[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院消化科,上海200011

出　　处：《临床消化病杂志》2008年第5期279-280,287,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的观察莫沙必利联合奥美拉唑治疗反流性食管炎的疗效。方法将100例患者随机分为治疗组(50例)和对照组(50例)。治疗组:奥美拉唑20mg,每日1次,莫沙必利5mg,每日3次口服。对照组:奥美拉唑20mg,每日1次口服。治疗前及治疗后2、4、6周计算患者症状积分。治疗后6周复查胃镜,观察胃镜下愈合率,并进行24h食管pH监测。结果治疗组临床有效率为100%,内镜下有效率为96%;对照组分别为88%和84%,两组比较差异有显著性(P<0.05)。6周后两组pH<4反流总次数及反流总时间百分率均显著降低(P<0.05),且两组间差异有统计学意义(P<0.05)。结论莫沙必利联合奥美拉唑治疗反流性食管炎比单用奥美拉唑具有更好的疗效。Objective To study the effect of mosapride and omeprazole on treatment of reflux esophagitis（RE）. Methods 100 RE patients were randomly divided into two groups, the treatment group （50 cases） ：5 mg of mosapride tid ,20 mg of omeprazole qd were taken orally;the control group （50 cases） ：20 mg omeprazole qd were taken orally. The symptoms were evaluated from pretreatment to every two weeks after the treatment. Recheck the endoscope findings at the end of 6 weeks. 24-hour esophageal pH was performed in two groups. Results The clinical curative rates were 100% in the treatment group and 88% in the control group, the efficient rate evaluation under endoscope were 96% ,84% respectively. After 6 weeks, the total number of pH 〈 4 and the total percentage of pH 〈4 were decreased in two group（ P 〈0. 05）. There was significant difference between the two groups （ P 〈 0. 05 ）. Conclusion The effect of mosapride combined with omeprazole on treating the reflux esophagitis was obviously superior to the other group.

关 键 词：反流性食管炎 莫沙必利 奥美拉唑 

分 类 号：R571[医药卫生—消化系统]