大肠平坦型腺瘤、隆起型腺瘤和腺癌的p53、c-myc和ki-67表达比较  

The Comparison of the Expression of p53,c-myc and ki-67 in colorectal Flat Adenoma Polypoid Adenoma and Adenocarcinoma

作　　者：钟选芳[1] 许岸高[1] 余志金[1] 张晓慧[1] 甘爱华[1] 陈惠新[1] 凌红[1] 

机构地区：[1]广东惠州市中心人民医院,广东医学院附属惠州医院消化科,惠州516001

出　　处：《临床消化病杂志》2008年第5期295-297,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的检测大肠平坦型腺瘤、隆起型腺瘤和浸润性大肠癌p53、c-myc和ki-67的表达水平,探讨其基因调控机制。方法选取2002至2006年间行结肠镜检查并经病理证实的平坦型、隆起型腺瘤和腺癌的病变标本,用免疫组织化学二步法检测p53、c-myc和ki-67的表达水平,分析三者表达水平在各组病变的差异和意义。结果p53、c-myc和ki-67在平坦型腺瘤、隆起型腺瘤和腺癌中阳性表达率分别为3.33%(1/30)、8.06%(5/62)和69.44%(25/35);33.33%(10/30)、58.06%(36/62)和80.56%(29/36);23.33%(7/30)、19.35%(12/62)和50.00%(18/36);在正常组织中均无明显表达。结论平坦型腺瘤、隆起型腺瘤和大肠癌三者具有不同的p53、c-myc和ki-67表达,提示三者的发生、发展可能存在不同基因调控机制,平坦型腺瘤的癌发生途径可能与隆起型腺瘤不同。Objective To study the gene regulation mechanism of colorectal flat adenoma, polypoid adenoma and adenocarcinoma by detecting the expression of p53, c-myc and ki-67 in these lesions. Methods Investigated the expression of p53, c-myc and ki-67 with two-step of immunohistochemistry method in flat adenomas, polypoid adenomas, invasive adenocarcinama which were performed in colonoscope and confirmed by histopathology from 2002 to 2006 and analyzed their differences and significance. Results The expression ratio of p53 ,c-myc and ki-67 in fiat adenomas ,polypoid adenomas and coloreetal cancer was 3.33% （1/30） ,8.06% （5/62） and 69.44% （25/35） respectively;33.33% （10/30） ,58. 06% （36/62） and 80. 56% （29/36） respectively;23.33% （7/30）, 19. 35% （12/62） and 50. 00% （18/36） respectively, but in nomal mucose most were negative. Conclusion The expressions of p53, c-myc and ki-67 were different in flast adenomas, polypoid adenomas and colorectal cancer indicated their gene regulation mechanism maybe different, the genetic mode for colorectal carcinogenesis of fiat adenomas maybe different from polypoid adenomas.

关 键 词：平坦型腺瘤 隆起型腺瘤 P53 C-MYE KI-67 

分 类 号：R735.34[医药卫生—肿瘤]