吲哚美辛对于食管贲门癌开胸术后发热的疗效观察  

Clinical Observation of Xiaoyantong on the Treatment of the Patients Performed Carcinoma of Esophagus and Cardiac Cancer

作　　者：祖金池[1] 黄呈森 李鹤飞[1] 孙振卿[1] 

机构地区：[1]河北大学附属医院胸外科,河北保定071000 [2]河北省承德卫校,河北承德067000

出　　处：《河北医学》2008年第11期1299-1301,共3页Hebei Medicine

摘　　要：目的:观察吲哚美辛退热栓对食管、贲门癌开胸术后发热的治疗效果。方法:选择河北大学附属医院胸外科食管、贲门癌手术后第一天发热38℃及以上患者57例。随机分为试验组和对照组两组。试验组给予消炎痛(吲哚美辛)退热栓,对照组安痛定(复方安基比林注射液)肌内注射,将两组用药后体温变化进行统计学处理,探讨消炎痛退热栓对食管、贲门癌术后的退热效果。结果:消炎痛退热栓组退热作用优于复方氨基比林注射液组,总有效率分别为96%和86%(P<0.05),显效率分别为86%和55%(P<0.01)。用药30min两组平均体温有差异(P<0.05)。2 h后两组平均体温分别降至36.3℃和37.5℃(P<0.01)。4 h后复方氨基比林注射液组体温回升。消炎痛退热栓组退热持续时间为(10.3±2.3)h,优于复方氨基比林注射液组的(6.1±2.1)h(P<0.01)。结论:消炎痛退热栓,用于食管、贲门癌手术后退热疗效满意,退热作用强,起效快,维持时间长。优于复方氨基比林肌内注射。而毒副作用如胃肠道反应(恶心、呕吐、腹痛、腹泻)。中枢神经系统症状(头痛、眩晕等),肝功能损伤、造血系统抑制(粒细胞减少等,再生障碍性贫血)。过敏反应(皮疹、哮喘)等发生无统计学差异。Objective： To explore the clinical effects of Xiaoyantong on the treatment of the patients performed carcinoma of esophagus and cardiac cancer. Methods：50 patients performed carcinoma of esophagus and cardiac cancer in our hospital, whose temperature was higher than 38℃ after operation, were divided into experimental group and the controls randomly. The patients in the experimental group were injected with Xiaoyantong , and the controls were injected Antongding through intramuscular injection. The temperature changes of all the patients were compared statistically. Results：The effects of Xiaoyantong was better than that of Antongding in relieving fever, the total effective rates of the two medicines were 96% and 86% respectivdy （P 〈0.05 ）. The improving effective rates were 86% and 55% respectively （ P 〈 0.01）. Considering the average temperature of the patients, there was a significant difference between the two groups after given medicines for 30 minutes （P 〈 0.05 ）. The average temperature of the patients in the experimental group and the controls reduced to 36.3℃ and 37.5℃ respectively （ P 〈0.01 ）.. The temperature of the patients in the controls began to rise after given medicine for 4 hours. The lasting time of the experimental group （10.3 ＋ 2.3h） was longer than that of the controls （6.1 ＋2. 1h） in relieving fever （P 〈0.01 ）. Conclusions：The results show that the relieving fever effects of Xiaoyantong is satisfactory, its effects are superior to that of Antongding, its power can last for long time： There is not any remarkable difference between the two groups as for the side - effects（ such as nausea, vomit, diarrhea, headache, granulocytopenia and aregenerative anemia ） and allergic reactions（ e.g. skin rash and asthma ）.

关 键 词：消炎痛栓 发热 食管术后 责门癌 疗 效 

分 类 号：R735[医药卫生—肿瘤]