降脂益肝冲剂对非酒精性脂肪肝的实验研究  

Effect of Jiangzhiyigan granula on nonalcoholic fatty liver disease

作　　者：薛翠芳[1] 赵和平[1] 

机构地区：[1]山西医科大学第一临床医学院综合科,太原030001

出　　处：《山西医科大学学报》2008年第11期979-981,1056,共4页Journal of Shanxi Medical University

摘　　要：目的观察降脂益肝冲剂对非酒精性脂肪肝模型的影响。方法雄性Wistar大鼠24只随机分为3组(每组8只):正常组给予普通饲料喂养,模型组和治疗组给予高脂饮食喂养。治疗组在实验开始后给予降脂益肝冲剂灌胃,同时模型组和正常组分别给予等量的生活饮用水灌胃,8周末处死各组大鼠。HE染色观察肝脏病理组织学改变,测定肝组织胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血栓素B2(TXB2)和6-酮-前列腺素F1α(6-Keto-PGF1α)含量及TXB2/6-Keto-PGF1α(T/PG比值)。结果治疗组肝脏脂肪变性程度明显改善,HDL-C和6-Ke-to-PGF1α含量显著高于模型组;TC、TG、LDL-C、TXB2和TXB2/6-Keto-PGF1α比值明显低于模型组。结论降脂益肝冲剂能使肝脏的脂肪变性程度减轻,使HDL-C和6-Keto-PGF1α含量升高,使TC、TG、LDL-C、TXB2含量和TXB2/6-Keto-PGF1α比值降低,这可能是其抗非酒精性脂肪肝的作用机制之一。Objective To investigate the effect of Chinese medicine Jiangzhiyigan granula on nonalcoholic fatty liver disease （NAFLD）in rats. Methods Twenty-four male Wistar rats were randomly divided into three groups（ n = 8 in each group）. The rats were fed with standard diet in normal group and with high-fat diet in model group and treated group. Then the rats were given Jiangzhiyigan granula in treated group at the beginning of experiment, while the same volume of life drinking water in normal group and model group. After eight weeks, the rats were executed. The pathological changes were observed, and the levels of liver total cholesterol（TC）, triglyeride（TG ）, HDL-C, LDL-C, TXB2, 6-Keto-PGF1α and TXB2/6-Keto-PGF1α were determined. Results Hepatosteatosis in treated group was obviously improved. The levels of HDL-C and 6-Keto-PGF1α in treated group were significantly higher than that in model group,while the levels of TC, TG, LDL-C and TXB2 and the ratio of TXB2/6-Keto-PGF1α were significantly lower than that in model group. Conclusion Jiangzhiyigan granula may lessen liver fatty degeneration, increase the levels of HDL-C and 6-Keto-PGF1α and decrease the levels of TC, TG, LDL-C, TXP, z and TXB2/6-Keto-PGF1α, which may be one of the mechanisms of anti-nonalcoholic fatty liver disease.

关 键 词：降脂益肝冲剂 非酒精性脂肪肝 脂质 血栓素B2 6-酮-前列腺素F1Α 

分 类 号：R575.5[医药卫生—消化系统]